D9500
2′-Deoxyguanosine 5′-monophosphate sodium salt hydrate
≥99% (HPLC), powder
Synonym(s):
5′-Deoxyguanylic acid, dGMP
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About This Item
Empirical Formula (Hill Notation):
C10H14N5O7P · xNa+ · yH2O
Molecular Weight:
347.22 (anhydrous free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
MDL number:
Assay:
≥99% (HPLC)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
Product Name
2′-Deoxyguanosine 5′-monophosphate sodium salt hydrate, ≥99% (HPLC)
Quality Level
assay
≥99% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
O.[Na+].NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](COP(O)([O-])=O)O3)C(=O)N1
InChI
1S/C10H14N5O7P.Na.H2O/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20;;/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17);;1H2/q;+1;/p-1/t4-,5+,6+;;/m0../s1
InChI key
UVKXYXSKMTUDML-FVALZTRZSA-M
Application
2′-Deoxyguanosine 5′-monophosphate sodium salt hydrate has been used:
- in reversed-phase high pressure liquid chromatography (HPLC) analysis
- to determine the effects of deoxy-mononucleotides on spontaneous proliferating CaCo-2 cell lines
- to determine its capacity to stimulate immune cell growth and function and used influenza virus antigen as an immunostimulant in vitro
2′-Deoxyguanosine 5′-monophosphate (dGMP) is used as a substrate of guanylate kinase(s) (EC 2.7.4.8) to form dGDP which upon phosphorylation to dGTP supports DNA biosynthesis. dGMP is use to study physiochemical characteristics of guanine based molecules.
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Mahmoud Kandeel et al.
Molecular and biochemical parasitology, 159(2), 130-133 (2008-04-01)
The present work describes cloning, expression, purification, characterization, and mutation of Plasmodium falciparum guanylate kinase (PlasmoDB ID PFI1420w). Amino-acid sequence alignment revealed important differences especially in K42-V51, Y73-A77, and F100-L110, which include residues important for kinase activity, and at helix
Ana-Maria Ruxandra Eftimie et al.
Roumanian archives of microbiology and immunology, 66(1-2), 22-25 (2008-10-22)
Guanylate kinase is a member of the nucleoside monophosphate (NMP) kinase family, a family of enzymes that despite having a low primary structure identity share a similar fold, which consists of three structurally distinct regions termed the CORE, LID, and
Brian G Gentry et al.
Biochemical pharmacology, 81(1), 43-49 (2010-09-18)
Many fraudulent nucleosides including the antivirals acyclovir (ACV) and ganciclovir (GCV) must be metabolized to triphosphates to be active. Cyclopropavir (CPV) is a newer, related guanosine nucleoside analog that is active against human cytomegalovirus (HCMV) in vitro and in vivo.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D9500-500MG | 04061833007044 |
| D9500-1G | 04061826690734 |
| D9500-100MG | 04061833007037 |