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E2127

β-Estradiol 3-(β-D-glucuronide) sodium salt

Name: &#946;-Estradiol 3-(&#946;-<SC>D</SC>-glucuronide) sodium salt
Brand: SIGMA

≥98% (HPLC), estradiol metbolite, powder

Synonym(s):

1,3,5(10)-Estratriene-3,17β-diol 3-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-glucuronide

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About This Item

Linear Formula:

C₂₄H₃₁O₈Na

CAS Number:

14982-12-8

Molecular Weight:

470.49

UNSPSC Code:

51111800

PubChem Substance ID:

24894454

NACRES:

NA.77

MDL number:

MFCD00056552

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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Product Name

β-Estradiol 3-(β-D-glucuronide) sodium salt,

sterility

non-sterile

Quality Level

200

assay

≥98% (HPLC)

form

powder

solubility

water: 10 mg/mL, clear to slightly hazy

shipped in

ambient

storage temp.

−20°C

SMILES string

[Na].CC12CCC3C(CCc4cc(OC5OC(C(O)C(O)C5O)C(O)=O)ccc34)C1CCC2O

InChI

1S/C24H32O8.Na.H/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30;;/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30);;

InChI key

JKYLXXZHJUQLMK-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecules

Application

β-Estradiol 3-(β-D-glucuronide) sodium salt has been used in estrogen administration. It has also been used to determine the amount of two types of glucuronidated estradiols such as estradiol-3- α glucuronide and estradiol-17- β glucuronide.

pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332

pcodes

P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品

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Protein quantification of UDP-glucuronosyltransferases 1A1 and 2B7 in human liver microsomes by LC-MS/MS and correlation with glucuronidation activities.

Yuichiro Sato et al.

Xenobiotica; the fate of foreign compounds in biological systems, 42(9), 823-829 (2012-03-23)

The aims of this study were to quantify absolute protein levels of uridine 5'-diphosphate-glucuronosyltransferases (UGTs) 1A1 and 2B7 in human liver microsomes (HLMs) and to investigate their correlation with marker activities. A quantification method for UGT1A1 and UGT2B7 in HLMs

A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles.

Linda B Tabas et al.

Analytical biochemistry, 310(1), 61-66 (2002-11-05)

This study investigated a high-throughput assay to measure multidrug resistance-associated protein (MRP1)-mediated uptake into membrane vesicles. Typically, a rapid filtration technique using a 12-filter vacuum manifold is used. We report here the development of a 96-well microtiter dish assay. MRP1-transfected

Direct, complex effects of estrogens on basal forebrain cholinergic neurons

Bora S H, et al.

Experimental Neurology, 194(2), 506-522 (2005)

Statistical correction for non-parallelism in a urinary enzyme immunoassay.

Kathleen A O'Connor et al.

Journal of immunoassay & immunochemistry, 25(3), 259-278 (2004-10-06)

Our aim was to develop a statistical method to correct for non-parallelism in an estrone-3-glucuronide (E1G) enzyme immunoassay (EIA). Non-parallelism of serially diluted urine specimens with a calibration curve was demonstrated in an EIA for E1G. A linear mixed-effects analysis

Estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronide.

Phillip M Gerk et al.

Drug metabolism and disposition: the biological fate of chemicals, 32(10), 1139-1145 (2004-07-29)

beta-estradiol 17-(beta-D-glucuronide) (E217G) is a well known cholestatic agent and substrate of multidrug resistance-associated protein 2 (Mrp2), whereas beta-estradiol 3-(beta-D-glucuronide) (E23G) is a noncholestatic regioisomer of E217G with unknown transport properties. The purpose of this study was to compare and

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Global Trade Item Number

SKU	GTIN
E2127-25MG	04061832849812
E2127-10MG	04061833602447
E2127-5MG	04061833602454

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