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Merck
CN

E8625

Eserine hemisulfate salt

Synonym(s):

Physostigmine hemisulfate salt

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About This Item

Empirical Formula (Hill Notation):
C15H21N3O2 · 0.5H2SO4
CAS Number:
Molecular Weight:
324.39
EC Number:
200-585-4
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
3828413
MDL number:
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storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1.CNC(=O)Oc4ccc5N(C)[C@H]6N(C)CC[C@@]6(C)c5c4

InChI

1S/2C15H21N3O2.H2O4S/c2*1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;1-5(2,3)4/h2*5-6,9,13H,7-8H2,1-4H3,(H,16,19);(H2,1,2,3,4)/t2*13-,15+;/m11./s1

InChI key

YYBNDIVPHIWTPK-KYJQVDHRSA-N

Biochem/physiol Actions

Acetylcholinesterase inhibitor that crosses the blood-brain barrier and forms a carbamylated enzyme complex with acetyl cholinesterase that degrades slowly.
Acetylcholinesterase inhibitor that crosses the blood-brain barrier.

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Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

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Vikas Trivedi et al.
Biomedical chromatography : BMC, 34(3), e4777-e4777 (2019-12-12)
The article describes a systematic study to overcome the matrix effect during chromatographic analysis of gemfibrozil, rivastigmine, telmisartan and tacrolimus from biological fluids using LC-ESI-MS/MS. All four methods were thoroughly developed by the appropriate choice of analytical column, elution mode
Anderson Ribeiro-Carvalho et al.
PloS one, 15(10), e0239017-e0239017 (2020-10-03)
Organophosphates are among the most used pesticides. Particularly, chlorpyrifos (CPF) is responsible for a number of deleterious effects on brain development, which may program behavioral changes later in life. Here, we investigated whether a regimen of early low level CPF
Y H Lu et al.
Journal of insect science (Online), 13, 9-9 (2013-07-25)
The aphids Sitobion avenae (Fabricius) and Rhopalosiphum padi (Linnaeus) (Hemiptera: Aphidiae) are serious pests on grain crops and usually coexist on late period of wheat growth in China. Bioassays showed that R. padi was more susceptible than S. avenae to
Jan-Oliver Hollnagel et al.
iScience, 23(7), 101316-101316 (2020-07-13)
Lactate shuttled from blood, astrocytes, and/or oligodendrocytes may serve as the major glucose alternative in brain energy metabolism. However, its effectiveness in fueling neuronal information processing underlying complex cortex functions like perception and memory is unclear. We show that sole
Sumonto Mitra et al.
Frontiers in aging neuroscience, 13, 714186-714186 (2021-09-04)
Gradual decline in cholinergic transmission and cognitive function occurs during normal aging, whereas pathological loss of cholinergic function is a hallmark of different types of dementia, including Alzheimer's disease (AD), Lewy body dementia (LBD), and Parkinson's disease dementia (PDD). Glial

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