F6256
5-Fluoro-1-(tetrahydro-2-furyl)uracil
Synonym(s):
Ftorafur, Tegafur
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About This Item
Empirical Formula (Hill Notation):
C8H9FN2O3
CAS Number:
Molecular Weight:
200.17
UNSPSC Code:
41106305
PubChem Substance ID:
EC Number:
241-846-2
MDL number:
form
solid
mp
171-173 °C (lit.)
storage temp.
2-8°C
SMILES string
FC1=CN(C2CCCO2)C(=O)NC1=O
InChI
1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)
InChI key
WFWLQNSHRPWKFK-UHFFFAOYSA-N
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
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Dikla Engel et al.
Journal of medicinal chemistry, 51(2), 314-323 (2008-01-01)
New and more potent prodrugs of the 5-fluorouracyl family derived by hydroxymethylation or acyloxymethylation of 5-fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione (tegafur, 1) are described. The anticancer activity of the butyroyloxymethyl-tegafur derivative 3 and not that of tegafur was attenuated by the antioxidant N-acetylcysteine, suggesting
Koji Oba
International journal of clinical oncology, 14(2), 85-89 (2009-04-25)
A consensus regarding standard adjuvant chemotherapy for curatively resected gastric cancer has not been obtained between Japan and the Western world. In order to evaluate the effect of a tegafur-based regimen (the most frequently used regimen in Japan) compared with
P M Hoff
Investigational new drugs, 18(4), 331-342 (2000-11-18)
Protracted intravenous regimens of fluorouracil (5-FU) may be superior and better tolerated than intravenous bolus dosing. An effective oral regimen would allow a protracted course of 5-FU without the need for central venous lines and the associated increase in complications.