G1506
Guanylyl(3′→5′)cytidine ammonium salt
Synonym(s):
GpC
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About This Item
Linear Formula:
C19H25N8O12P · NH3
CAS Number:
Molecular Weight:
605.45
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
Form:
solid
Storage temp.:
−20°C
form
solid
storage temp.
−20°C
SMILES string
N.NC1=NC(=O)c2ncn(C3OC(CO)C(OP(O)(=O)OCC4OC(C(O)C4O)N5C=CC(N)=NC5=O)C3O)c2N1
InChI
1S/C19H25N8O12P.H3N/c20-8-1-2-26(19(33)23-8)16-11(30)10(29)7(38-16)4-36-40(34,35)39-13-6(3-28)37-17(12(13)31)27-5-22-9-14(27)24-18(21)25-15(9)32;/h1-2,5-7,10-13,16-17,28-31H,3-4H2,(H,34,35)(H2,20,23,33)(H3,21,24,25,32);1H3
InChI key
PPSONIOCBRREER-UHFFFAOYSA-N
Application
Guanylyl(3′5′)cytidine is an oligonucleotide pyrimidine dimer used as a substrate to study the specificity and kinetics of various RNases such as RNase T1 and its mutations.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Martin Vincent et al.
Genome biology, 18(1), 38-38 (2017-02-23)
The study of epigenetic heterogeneity at the level of individual cells and in whole populations is the key to understanding cellular differentiation, organismal development, and the evolution of cancer. We develop a statistical method, epiG, to infer and differentiate between
Marc Struhalla et al.
Chembiochem : a European journal of chemical biology, 5(2), 200-205 (2004-02-05)
Although ribonuclease T1 (RNase T1) is one of the best-characterized proteins with respect to structure and enzymatic action, numerous attempts at altering the specificity of the enzyme to cleave single-stranded RNA at the 3'-side of adenylic instead of guanylic residues
Rico Czaja et al.
Biochemistry, 43(10), 2854-2862 (2004-03-10)
Attempts to alter the guanine specificity of ribonuclease T1 (RNase T1) by rational or random mutagenesis have failed so far. The RNase T1 variant RV (Lys41Glu, Tyr42Phe, Asn43Arg, Tyr45Trp, and Glu46Asn) designed by combination of a random and a rational
Francisco Requena et al.
Scientific reports, 9(1), 8140-8140 (2019-06-01)
Recent technical advances highlight that to understand mammalian development and human disease we need to consider transcriptional and epigenetic cell-to-cell differences within cell populations. This is particularly important in key areas of biomedicine like stem cell differentiation and intratumor heterogeneity.
Elena Loreti et al.
Plant physiology, 182(1), 287-300 (2019-07-31)
In plants, hypoxia can be induced by submergence, and the lack of oxygen impairs mitochondrial respiration, thus affecting the plant's energy status. Hypoxia has major effects on gene expression; these changes induce key responses that help meet the needs of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| G1506-5MG | 04061833271131 |
| G1506-1MG | 04061826674871 |
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