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Merck
CN

G1639

D-(+)-Galactosamine hydrochloride

BioReagent, suitable for cell culture

Synonym(s):

2-Amino-2-deoxy-D-galactopyranose hydrochloride, D-Chondrosamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C6H13NO5 · HCl
CAS Number:
1772-03-8
Molecular Weight:
215.63
PubChem Substance ID:
24895072
UNSPSC Code:
12352209
MDL number:
MFCD00135830
NACRES:
NA.75
EC Number:
217-198-1
Beilstein/REAXYS Number:
3697825

Key Documents

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biological source

fish cartilage (shark)

Quality Level

200

product line

BioReagent

assay

≥99%

technique(s)

cell culture | mammalian: suitable

impurities

Glucosamine, essentially free

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO

InChI

1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1

InChI key

CBOJBBMQJBVCMW-NQZVPSPJSA-N

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Application

D-(+)-Galactosamine hydrochloride has been used to:
  • induce livery injury
  • inflammatory liver injury
  • acute liver failure (ALF) in mice

Biochem/physiol Actions

Galactosamine (D-GalN) is synthesized from galactose and is potential hepatotoxic agent. D-GalN in combination with lipopolysaccharide leads to the development of lethal liver injury and hepatic failure. It sensitizes cells to the toxic effects of the cytokine in particular the tumor necrosis factor(TNF).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000522529
0000522529
0000479915
0000479916
0000479916

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GABA, gamma-Aminobutyric Acid, Protects Against Severe Liver Injury
Hata T, et al.
The Journal of Surgical Research, 236, 172-183 (2019)
Yao Wang et al.
Journal of inflammation research, 14, 1473-1485 (2021-04-23)
The glycolysis pathway of M1 macrophages is a key factor affecting the inflammatory response. The aim of this article is to investigate the role of histone deacetylase 6 (HDAC6) in the M1 macrophage glycolysis pathway during acute liver failure (ALF).
Marina S Drutskaya et al.
Journal of leukocyte biology, 107(6), 933-939 (2020-02-11)
Systemic TNF neutralization can be used as a therapy for several autoimmune diseases. To evaluate the effects of cell type-restricted TNF blockade, we previously generated bispecific antibodies that can limit TNF secretion by myeloid cells (myeloid cell-specific TNF inhibitors or
Catalpol protects mice against Lipopolysaccharide/D-galactosamine-induced acute liver injury through inhibiting inflammatory and oxidative response
Zhang H, et al.
Testing, 9(3), 3887-3887 (2018)
The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro
Bai X, et al.
British Journal of Pharmacology, 174(1), 41-56 (2017)
View All Related Papers

Global Trade Item Number

SKUGTIN
G1639-1G04061833628300
G1639-100MG04061833628294
G1639-5G04061833628317

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