H141
S(−)-8-Hydroxy-DPAT hydrobromide
solid
Synonym(s):
S(−)-8-OH-DPAT HBr
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About This Item
Empirical Formula (Hill Notation):
C16H25NO · HBr
CAS Number:
Molecular Weight:
328.29
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
form
solid
optical activity
[α]25/D −67.8° in methanol(lit.)
color
white
SMILES string
Br.CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
InChI
1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m0./s1
InChI key
BATPBOZTBNNDLN-UQKRIMTDSA-N
Biochem/physiol Actions
Partial 5-HT1A serotonin receptor agonist.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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L Björk et al.
Journal of medicinal chemistry, 32(4), 779-783 (1989-04-01)
The enantiomers of the N,N-dimethylamino (1), N,N-diethylamino (2), and N,N-dibutylamino (4) derivatives of 8-hydroxy-2-(dipropylamino)tetralin (8-OH DPAT; 3) have been synthesized. The compounds have been tested for activity at central 5-hydroxytryptamine and dopamine receptors by use of biochemical and behavioral tests
B Restrepo et al.
Pharmacology, 90(3-4), 169-176 (2012-09-06)
We investigated the mechanisms involved in the 5-hydroxytriptaminergic inhibitory action on the pressor responses elicited by sympathostimulation in long-term-diabetic pithed rats. Diabetes was induced in rats by alloxan administration. Eight weeks later, the animals were anaesthetized and pithed. The action
Rachel L Dennis et al.
Aggressive behavior, 39(2), 91-98 (2013-02-07)
Prenatal stress can alter the serotonin (5-HT) system in the developing and adult brain and lead to mood and behavioral disorders in children and adults. The chicken provides a unique animal model to study the effects of embryonic stressors on