H5160
Hyperforin
≥85% (HPLC), Use secondary activity, solution
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About This Item
Empirical Formula (Hill Notation):
C35H52O4
CAS Number:
Molecular Weight:
536.78
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-659-6
MDL number:
Product Name
Hyperforin, ≥85% (HPLC)
Quality Level
assay
≥85% (HPLC)
form
solution
storage temp.
−20°C
SMILES string
CC(C)C(=O)[C@@]12C(O)=C(C\C=C(\C)C)C(=O)[C@@](C\C=C(/C)C)(C[C@H](C\C=C(\C)C)[C@@]1(C)CC\C=C(\C)C)C2=O
InChI
1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1
InChI key
IWBJJCOKGLUQIZ-HQKKAZOISA-N
General description
Hyperforin is a phloroglucinol component of St. John′s wort and a pregnane X receptor ligand.
Application
Hyperforin may be used:
- as a reference standard for calibration curve generation in high-perfornamce liquid chromatography (HPLC) analysis
- to test its cytotoxic effect and apoptosis induction in mouse embryonic cells
- as a pregnane X receptor (PXR) in porcine brain capillary endothelial cells for transport assay
Biochem/physiol Actions
Hyperforin is an active antidepressant and an inhibitor of cytochrome P450 3A4 (CYP3A). It elicits antioxidant and antibacterial activity. Hyperforin is also embryotoxic and inhibits tumor proliferation. It effectively inhibits dopamine, serotonin and norepinephrine.
Disclaimer
Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
Storage Class
3 - Flammable liquids
wgk
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
危险化学品
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Mohamed A Farag et al.
Planta medica, 78(5), 488-496 (2012-01-25)
The growing interest in the efficacy of phytomedicines and herbal supplements but also the increase in legal requirements for safety and reliable contents of active principles drive the development of analytical methods for the quality control of complex, multicomponent mixtures
L B Moore et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(13), 7500-7502 (2000-06-15)
St. John's wort (Hypericum perforatum) is an herbal remedy used widely for the treatment of depression. Recent clinical studies demonstrate that hypericum extracts increase the metabolism of various drugs, including combined oral contraceptives, cyclosporin, and indinavir. In this report, we
Jeffry Adiwidjaja et al.
Clinical pharmacokinetics, 58(7), 911-926 (2019-01-25)
Herb-drug interactions with St John's wort (SJW) have been widely studied in numerous clinical studies. The objective of this study was to develop and evaluate a physiologically based pharmacokinetic (PBPK) model for hyperforin (the constituent of SJW responsible for interactions)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H5160-250UG | 04061833797754 |