Anti-dimethyl-Histone H1.4 (diMe-Lys²⁶) antibody produced in rabbit

dimethylated synthetic peptide corresponding to amino acids 22-23 (diMeLys²⁶) of human histone H1.4.

Anti-dimethyl-Histone H1.4 (diMe-Lys26) antibody produced in rabbit is suitable for western blotting at a concentration of 0.5-1μg/mL using acid-extracted fraction of HL60 cells.

ChIP validated

The building block of chromatin is the nucleosome which is comprised of an octamer of core histones (H2A, H2B, H3, and H4) around which 147 bp of DNA are wrapped. In mammalian cells, four histone H1 variants (H1.2 to H1.5) are present in all somatic cells, and a fifth (H1.1) is restricted to thymus, testis, and spleen and possibly lymphocytic and neuronal cells. Histone H1.4 is di-methylated or acetylated at Lys26. Lys26 is located within the flexible N-terminal domain of H1.4, just preceding the globular domain.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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