I8000
2-Iodosobenzoic acid
≥98% (TLC)
Synonym(s):
IBA
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About This Item
Linear Formula:
OIC6H4CO2H
CAS Number:
Molecular Weight:
264.02
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
206-159-4
MDL number:
Beilstein/REAXYS Number:
1939973
Product Name
2-Iodosobenzoic acid,
assay
≥98% (TLC)
Quality Level
form
powder
color
white to off-white
mp
230 °C (dec.) (lit.)
storage temp.
−20°C
SMILES string
OC(=O)c1ccccc1[I]=O
InChI
1S/C7H5IO3/c9-7(10)5-3-1-2-4-6(5)8-11/h1-4H,(H,9,10)
InChI key
IFPHDUVGLXEIOQ-UHFFFAOYSA-N
Application
For cleavage of tryptophanyl peptide bonds.
Biochem/physiol Actions
2-Iodosobenzoic acid (IBA) may be used to study enzyme structure and activity. IBA is used as an oxidant which oxidizes vicinal sulfhydryls to disulfides (cysteine residues) within enzymes leading to their inactivation or conformational changes. IBA is also used to cleave tryptophanyl peptide bonds.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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M F Drincovich et al.
Biochimica et biophysica acta, 1206(1), 10-16 (1994-05-18)
Incubation of C4 NADP-malic enzyme from maize leaves with the oxidant o-iodosobenzoate leads to the reversible and complete inactivation of the enzyme. The time-course of inactivation is biphasic with the rate depending on the o-iodosobenzoate concentration. The inactivation is partially
Tom Waters et al.
Organic & biomolecular chemistry, 6(14), 2530-2533 (2008-07-05)
The gas phase anion proton affinities of the periodinane anions IBX- and IBA- were examined using mass spectrometry-based experiments, and estimated as 1300 +/- 25 and 1390 +/- 10 kJ mol(-1), respectively. The experimental results were supported by theoretical calculations
W F Liu et al.
Toxicology letters, 45(2-3), 289-298 (1989-02-01)
o-Iodosobenzoic acid (IBA), in a surfactant micellar medium, is a rapid and efficient catalyst for the hydrolysis of organophosphate (OP) esters. Since little is known about the toxicity of IBA, a primary screen of neurobehavioral toxicity was evaluated in male
A Magalhaes et al.
FEBS letters, 329(1-2), 116-120 (1993-08-23)
The complete amino acid sequence of a thrombin-like enzyme with gyroxin activity isolated from the venom of the bushmaster snake Lachesis muta muta was determined by automated and DABITC/PITC microsequencing of the intact protein; fragments derived from it by separate
C Longo et al.
The International journal of biochemistry, 24(1), 133-143 (1992-01-01)
1. o-Iodosobenzoic acid (IOB) caused the formation of a disulfide bridge between SH1 and SH2 groups of myosin SF1 rendering inactive its ATPase activity. 2. IOB at high concentrations provoked fragmentation of SF1 at its tryptophan residues. 3. The main
Global Trade Item Number
| SKU | GTIN |
|---|---|
| I8000-1G | 04061833858448 |
| I8000-5G | 04061832469072 |
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