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I9759

Ile-Pro-Ile

Name: Ile-Pro-Ile
Brand: SIGMA

≥97% (HPLC), Dipeptidyl peptidase IV inhibitor, powder

Synonym(s):

Diprotin A

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₃₁N₃O₄

CAS Number:

90614-48-5

Molecular Weight:

341.45

UNSPSC Code:

51111800

PubChem Substance ID:

24896160

NACRES:

NA.77

MDL number:

MFCD00038707

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

200

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Product Name

Ile-Pro-Ile, ≥97% (HPLC)

Quality Level

200

assay

≥97% (HPLC)

form

powder

solubility

water: 1 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CCC(C)C(N)C(=O)N1CCCC1C(=O)NC(C(C)CC)C(O)=O

InChI

1S/C17H31N3O4/c1-5-10(3)13(18)16(22)20-9-7-8-12(20)15(21)19-14(17(23)24)11(4)6-2/h10-14H,5-9,18H2,1-4H3,(H,19,21)(H,23,24)

InChI key

JNTMAZFVYNDPLB-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Ile-Pro-Ile has been used as a supplement for blood collection for hormone measurement and used in Islets cell culture to stabilize glucagon-like peptide-1 (GLP-1). It has also been used to inhibit the breakdown of gonadotropin-inhibitory hormone (GnIH) following serum collection.

Biochem/physiol Actions

Dipeptidyl peptidase IV Inhibitor. Inhibits entry of HIV-1 or HIV-2

Inhibitor of dipeptidyl peptidase IV. Inhibits entry of HIV-1 or HIV-2 into T lymphoblastoid and monocytoid cell lines.

Features and Benefits

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Effects of acute dietary weight loss on postprandial plasma bile acid responses in obese insulin resistant subjects.

F Samuel van Nierop et al.

Clinical nutrition (Edinburgh, Scotland), 36(6), 1615-1620 (2016-10-25)

Bile acids (BA) are pleiotropic hormones affecting glucose and lipid metabolism. The physiochemical properties of different BA species affect their enterohepatic dynamics and their affinity for bile acid receptors. The BA pool composition is altered in patients with type 2

Effect of gonadotropin-inhibitory hormone on luteinizing hormone secretion in humans

George JT, et al.

Clinical Endocrinology, 86(5), 731-738 (2017)

The gut hormone receptor GIPR links energy availability to the control of hematopoiesis.

Gemma Pujadas et al.

Molecular metabolism, 39, 101008-101008 (2020-05-12)

Glucose-dependent insulinotropic polypeptide (GIP) conveys information from ingested nutrients to peripheral tissues, signaling energy availability. The GIP Receptor (GIPR) is also expressed in the bone marrow, notably in cells of the myeloid lineage. However, the importance of gain and loss

Pancreatic alpha cell-derived glucagon-related peptides are required for beta cell adaptation and glucose homeostasis

Traub S, et al.

Cell Reports, 18(13), 3192-3203 (2017)

Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides.

Pádraigín A Harnedy et al.

Food research international (Ottawa, Ont.), 106, 598-606 (2018-03-28)

Large quantities of low-value protein rich co-products, such as salmon skin and trimmings, are generated annually. These co-products can be upgraded to high-value functional ingredients. The aim of this study was to assess the antidiabetic potential of salmon skin gelatin

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Articles

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Global Trade Item Number

SKU	GTIN
I9759-5MG	04061833865774
I9759-25MG	04061833865767

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