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K1265

Ki8751 hydrate

Name: Ki8751 hydrate
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluoro-phenyl]-urea hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₁₈F₃N₃O₄ · xH₂O

CAS Number:

228559-41-9

Molecular Weight:

469.41 (anhydrous basis)

UNSPSC Code:

12352200

MDL number:

MFCD09971092

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Properties

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >20 mg/mL

storage temp.

−20°C

SMILES string

COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC

Description

Biochem/physiol Actions

Ki8751 is a potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC₅₀= 0.9 nM).

pictograms

GHS07

signalword

Warning

hcodes

H315

Hazard Classifications

Skin Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

117K4620

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Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.

Kazuo Kubo et al.

Journal of medicinal chemistry, 48(5), 1359-1366 (2005-03-04)

N-Phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas were found to be a novel class of potent inhibitors for the vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase through synthetic modifications of a lead compound and structure-activity relationship studies. A representative compound 6ab, termed Ki8751, inhibited