L5022
[D-Lys6]-LH-RH
≥95% (HPLC), powder
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About This Item
Empirical Formula (Hill Notation):
C59H84N18O13
CAS Number:
Molecular Weight:
1253.41
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥95% (HPLC)
form
powder
UniProt accession no.
storage temp.
−20°C
SMILES string
CC(C)CC(NC(=O)C(CCCCN)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc4cnc[nH]4)NC(=O)C5CCC(=O)N5)C(=O)NC(CCCNC(N)=N)C(=O)N6CCCC6C(=O)NCC(N)=O
Gene Information
human ... GNRH1(2796)
Biochem/physiol Actions
LH-RH agonist. It has been conjugated to cytotoxic compounds such as methotrexate (MTX), doxorubicin (DOX), and glutaryl-2-(hydroxymethyl)anthraquinone (G-HMAQ), and together with other conjugated LH-RH analogs comprise a class of targeted chemotherapeutic agents for cancers expressing receptors for LH-RH.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Repr. 1B
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Regulatory Information
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K Nikolics et al.
Endocrinologia experimentalis, 18(2), 109-116 (1984-06-01)
Primary rat pituitary cell culture system was used to investigate LH releasing activity of dimeric and oligomeric LH-RH agonists. In addition, peptides containing both agonistic as well as inhibitory segments were tested in order to find out which sequence overrules
D Pati et al.
European journal of biochemistry, 242(1), 36-40 (1996-11-15)
Recently we have demonstrated that the human hepatocellular carcinoma-derived cell lines, HepG2 and HuH7, contain gonadotropin-releasing hormone (gonadoliberin) receptors and respond to various molecular forms of gonadoliberin in terms of suppressed proliferation in vitro. This study provides the first demonstration
G V Childs et al.
Peptides, 4(4), 549-555 (1983-07-01)
These studies describe the application of new cytochemical stains that co-localize a biotin-labeled gonadotropin releasing hormone (GnRH) analog and FSH or LH in the same field or cell. Pituitary monolayer cells were stimulated with the [D-Lys6] GnRH analog or the