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Merck
CN

L8000

L-Leucine

≥98% (HPLC), suitable for ligand binding assays

Synonym(s):

(S)-2-Amino-4-methylpentanoic acid

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About This Item

Linear Formula:
(CH3)2CHCH2CH(NH2)CO2H
CAS Number:
61-90-5
Molecular Weight:
131.17
NACRES:
NA.26
PubChem Substance ID:
24896488
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-522-0
MDL number:
MFCD00002617
Beilstein/REAXYS Number:
1721722

Key Documents

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Product Name

L-Leucine, reagent grade, ≥98% (HPLC)

grade

reagent grade

Quality Level

200

assay

≥98% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

impurities

isoleucine and methionine, essentially free

color

white to off-white

mp

>300 °C (lit.)

application(s)

peptide synthesis

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

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Application

L-Leucine has been used as an agonist of mechanistic target of rapamycin (mTOR) to determine whether AMPK/mTOR pathway is involved in berberine-mediated autophagy in J774A.1 cells. It has also been used for the selection of transformed cells.

Biochem/physiol Actions

Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to the formation of ketone bodies.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000352621
0000352621
BCCN4277
BCCM7378
0000294901

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Susan A Masino
Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease (2016)
Markerless Gene Editing in the Hyperthermophilic Archaeon Thermococcus kodakarensis
Alexandra m
Bio-protocol (2017)
Dr. Victor Prisk
The Leucine Factor Diet: The Scientifically-Proven Approach to Combat Sugar, Burn Fat and Build Muscle (2015)
Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway
Xiaodi Fan
Journal of Translational Medicine (2015)
Sergio R Santa Maria et al.
Astrobiology (2020-01-07)
The biological risks of the deep space environment must be elucidated to enable a new era of human exploration and scientific discovery beyond low earth orbit (LEO). There is a paucity of deep space biological missions that will inform us
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Related Content

Product Information Sheet - L8000

Product Information Sheet

Global Trade Item Number

SKUGTIN
L8000-1KG04061833965801
L8000-1G-KC04061824071559
L8000-250G04061835367214
L8000-25G04061835367221
L8000-50G04061835367238
L8000-100G04061833965795

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