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M204

p-MPPI monohydrochloride

Name: <I>p</I>-MPPI monohydrochloride
Brand: SIGMA

solid, ≥98% (HPLC)

Synonym(s):

4-Iodo-N-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)benzamide monohydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₂₇IN₄O₂ · HCl

CAS Number:

220643-77-6

Molecular Weight:

578.87

UNSPSC Code:

12352200

PubChem Substance ID:

24278106

MDL number:

MFCD00467897

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Properties

assay

≥98% (HPLC)

form

solid

color

white

solubility

H₂O: 2.4 mg/mL

SMILES string

Cl.COc1ccccc1N2CCN(CC2)CCN(C(=O)c3ccc(I)cc3)c4ccccn4

Gene Information

human ... HTR1A(3350)

Description

Biochem/physiol Actions

Selective 5-HT_1A serotonin receptor antagonist that crosses the blood-brain barrier.

Legal Information

Manufactured and sold under license from University of Pennsylvania, U.S. Patent 5,744,121.

Disclaimer

Solutions are heat sensitive.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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A potential 5-HT1A receptor antagonist: p-MPPI.

H F Kung et al.

Life sciences, 55(19), 1459-1462 (1994-01-01)

A potential 5-HT1A receptor antagonist, p-MPPI, 4-(2'-methoxy-)phenyl-1-[2'-(n-2"-pyridinyl)-p-iodobenzamido-]ethy l- piperazine, was developed. The [125I]p-MPPI demonstrated high affinity and selectivity toward 5-HT1A receptors; Kd = 0.36 nM and Bmax = 264 fmol/mg of protein in rat hippocampal membrane homogenates. The binding is

4-(2'-Methoxy-phenyl)-1-[2'-(n-2"-pyridinyl)-p-iodobenzamido]-ethyl- piperazine ([125I]p-MPPI) as a new selective radioligand of serotonin-1A sites in rat brain: in vitro binding and autoradiographic studies.

M P Kung et al.

The Journal of pharmacology and experimental therapeutics, 272(1), 429-437 (1995-01-01)

Binding characteristics of a radioiodinated serotonin-1A (5-HT1A) receptor antagonist, 4-(2'-methoxy-phenyl)-1-[2'-(n-2"-pyridinyl)-p- iodobenzamido]-ethyl-piperazine ([125I]p-MPPI) were evaluated using in vitro homogenate binding and autoradiographic techniques in rat brains. [125I]p-MPPI displayed a Kd value of 0.32 +/- 0.04 nM (in the presence of MgCl2)

In vivo binding of [¹²⁵I]4-(methoxyphenyl)-1-[2'-(N-2″-pyridinyl)-p-iodo-benzamido]-ethylpiperazine, p-MPPI, to 5HT_1A receptors in rat brain.

Kung, et al.

Synapse, 18, 459-459 (1994)

Global Trade Item Number

SKU	GTIN
569747-10G	04061832597225
569747-100MG	04061832597218
569747-2G	04061832597232
569747-25G	04065270988423
569747-500MG	04061832597249
919764-250MG	04065265447164
919764-1G	04065265447157