M9125
Methapyrilene hydrochloride
Synonym(s):
N,N-Dimethyl-N′-(2-pyridinyl)-N′-(2-thienylmethyl)-1,2-ethanediamine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C14H19N3S · HCl
CAS Number:
Molecular Weight:
297.85
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
205-184-8
MDL number:
SMILES string
Cl.CN(C)CCN(Cc1cccs1)c2ccccn2
Gene Information
human ... HRH1(3269)
Biochem/physiol Actions
H1 histamine receptor antagonist. Potent liver carcinogen in rats.
Other Notes
Supplied only to established institutions. Telephone orders not accepted.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
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S Noguchi et al.
Physiology & behavior, 51(6), 1123-1127 (1992-06-01)
The effects of antidepressants [(+)-oxaprotiline, (-)-oxaprotiline, imipramine, maprotiline, and trazodone] and antihistamines (mepyramine, dimethindene, ketotifen, methapyrilene, and antazoline) on muricidal behaviour in olfactory bulbectomized rats were investigated. All drugs except for dimethindene, which only minimally passes across the blood-brain barrier
H K Lee et al.
Mutation research, 341(2), 77-82 (1994-12-01)
The antihistaminic agent methapyrilene hydrochloride (MPH, CAS No. 135-23-9) has been reported as a potent rat hepatocarcinogen. However, neither the action mechanism nor mutagenicity of MPH have been clearly elucidated yet. Chromosomal aberration (CA) tests were performed with MPH in
G S Ratra et al.
Toxicological sciences : an official journal of the Society of Toxicology, 46(1), 185-196 (1999-02-03)
The mechanisms by which the antihistamine drug methapyrilene causes acute periportal hepatotoxicity in rats are not yet elucidated. This study investigated the effects of modulators of cytochrome P450 (CYP) activity on the hepatotoxicity of methapyrilene and also the effect of