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Merck
CN

N144

Nitrendipine

>95%, powder

Synonym(s):

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester

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About This Item

Empirical Formula (Hill Notation):
C18H20N2O6
CAS Number:
39562-70-4
Molecular Weight:
360.36
NACRES:
NA.77
PubChem Substance ID:
24277857
UNSPSC Code:
12352200
EC Number:
254-513-1
MDL number:
MFCD00082255
Assay:
>95%
Form:
powder
Quality level:
200

Key Documents

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Quality Level

200

assay

>95%

form

powder

color

yellow to green

solubility

methanol: 15 mg/mL, DMSO: 17.5 mg/mL, H2O: insoluble

SMILES string

CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC

InChI

1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3

InChI key

PVHUJELLJLJGLN-UHFFFAOYSA-N

Gene Information

human ... ADORA3(140), CACNG1(786), KCNH1(3756), TTR(7276)
rat ... Adora1(29290), Adora2a(25369)

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Related Categories

Biochem/physiol Actions

Ca2+ channel blocker; anti-hypertensive.

Storage Class

11 - Combustible Solids

wgk

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
028F08941
038H4745

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Xi Zhang et al.
International journal of pharmaceutics, 431(1-2), 45-52 (2012-05-01)
A novel active and multi-dose dry powder inhaler (DPI) was developed and evaluated to deliver a small quantity (100-500 μg) of pure drug without any excipient. This dry powder inhaler utilized two compressed air flows to dispense and deliver drug
Dengning Xia et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(5), 446-454 (2012-04-10)
The amorphous-to-crystalline transformation of nitrendipine was investigated using Raman spectroscopy and X-ray powder diffraction (XRPD). The nucleation and growth rate of crystalline nitrendipine in a medium containing poly (vinyl alcohol) (PVA) and polyethylene glycol (PEG 200) were quantitatively determined using
Dewei Shang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(30), 3459-3464 (2011-10-05)
A HPLC method with on-line solid phase extraction (SPE) and DAD detection was developed for the simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat (SHR) plasma. Plasma samples (100 μL) were injected directly onto a CAPCELL MF C(8)
Xiaowei Shi et al.
Journal of pharmaceutical and biomedical analysis, 56(5), 1101-1105 (2011-09-03)
A novel and sensitive method utilizing high performance liquid chromatography coupled with electrospray ionization source tandem mass spectrometry (LC-ESI-MS(3)) was developed for the first time in order to analyze nitrendipine in human plasma samples. Human plasma samples were prepared by
Swathi Voruganti et al.
European journal of drug metabolism and pharmacokinetics, 37(2), 77-81 (2011-11-22)
Pomegranate juice (PJ) is known to be a potent inhibitor of human cytochrome enzymes. The purpose of this study was to investigate the effect of acute and chronic PJ on the pharmacokinetics of oral nitrendipine (10 mg/kg) in rabbits. Male New
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Global Trade Item Number

SKUGTIN
N144-100MG04061832962214
N144-25MG04061832962221
N144-500MG04061832962238

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