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Merck
CN

N2881

4-Nitrophenyl phenylphosphonate

adenosine receptor agonist, 5′-Nucleotide Phosphodiesterase substrate

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About This Item

Empirical Formula (Hill Notation):
C12H10NO5P
CAS Number:
Molecular Weight:
279.19
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
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Quality Level

assay

≥98% (TLC)

form

powder

solubility

acetone: 50 mg/mL, clear, faintly yellow

storage temp.

−20°C

SMILES string

OP(=O)(Oc1ccc(cc1)N(=O)=O)c2ccccc2

InChI

1S/C12H10NO5P/c14-13(15)10-6-8-11(9-7-10)18-19(16,17)12-4-2-1-3-5-12/h1-9H,(H,16,17)

InChI key

NRGZTHQFAQCJCQ-UHFFFAOYSA-N

General description

5′-Nucleotide Phosphodiesterase substrate


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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M Labadie et al.
Biochimie, 61(9), 1091-1094 (1979-01-01)
A "Batch" microcalorimeter is used at 30 degrees C for the study of the hydrolysis of 4-nitro-phenylphenylphosphonate with a calf-intestinal phosphonate esterase, in a tris buffer, pH 8. The yield of enzymatic hydrolysis is estimated by spectrophotometric determination of the
Hydrolysis of a phosphonate ester catalyzed by an enzyme from Dictyostelium discoideum.
E F Rossomando et al.
Archives of biochemistry and biophysics, 197(1), 364-366 (1979-10-01)
H J Deussen et al.
Bioorganic & medicinal chemistry, 8(3), 507-513 (2000-03-25)
A bifunctional activity label (8) for directed molecular evolution of lipolytic enzymes has been designed and synthesized. The structure is composed of a 4-nitrophenyl activated phosphonate, that is, a suicide substrate of lipases/esterases, connected to a biotin moiety through a



Global Trade Item Number

SKUGTIN
N2881-1G04061826691915