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P126

Pirenperone

>97%, solid

Synonym(s):

3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2-methyl-4H-pyrido-[1,2-a] pyrimidin-4-one, R-47,465

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About This Item

Empirical Formula (Hill Notation):
C23H24FN3O2
CAS Number:
75444-65-4
Molecular Weight:
393.45
UNSPSC Code:
12352200
PubChem Substance ID:
24278110
EC Number:
278-213-5
MDL number:
MFCD00069332
Assay:
>97%
Form:
solid
Quality level:
200
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Quality Level

200

assay

>97%

form

solid

color

light yellow

solubility

0.1 M HCl: 11 mg/mL, methanol: 2.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 5.0 mg/mL

SMILES string

CC1=C(CCN2CCC(CC2)C(=O)c3ccc(F)cc3)C(=O)N4C=CC=CC4=N1

InChI

1S/C23H24FN3O2/c1-16-20(23(29)27-12-3-2-4-21(27)25-16)11-15-26-13-9-18(10-14-26)22(28)17-5-7-19(24)8-6-17/h2-8,12,18H,9-11,13-15H2,1H3

InChI key

HXCNRYXBZNHDNE-UHFFFAOYSA-N

Gene Information

human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)

Biochem/physiol Actions

5-HT2 serotonin receptor antagonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
048H4736

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S G Holtzman et al.
Pharmacology, biochemistry, and behavior, 47(3), 575-578 (1994-03-01)
The results of studies on mice indicate that the antinociceptive effects of kappa-opioid agonists are due, in part, to activation of the 5-HT2 type of serotonin receptor. One objective of this study was to determine if the discriminative effects of
M J Walker et al.
Psychopharmacology, 113(3-4), 527-533 (1994-01-01)
Several studies have demonstrated a paradoxical form of antinociception induced by the repeated administration of opioid antagonists accompanied by exposure to a painful stimulus. The underlying mechanism of this naloxone-induced antinociception (NIA) is still unknown, but the results of several
J C Winter et al.
Pharmacology, biochemistry, and behavior, 62(3), 543-547 (1999-03-18)
Stimulus control was established in a group of nine rats using a dose of EGb 761 of 10 mg/kg, administered i.p., 15 min before training. A two-lever operant task using a fixed-ratio 10 schedule of sweetened milk reinforcement was used.
C Goodrich et al.
Physiology & behavior, 46(2), 203-209 (1989-08-01)
Experiments were designed to distinguish between central and peripheral effects on temperature preference and body temperature of drugs injected intraperitoneally (IP) in infant mice ranging in age from 3 to 10 days postpartum. These compared a drug restricted to the
L A Dykstra et al.
Psychopharmacology, 112(1), 116-120 (1993-01-01)
The kappa opioid, U50,488, was examined alone and in combination with the 5HT2 antagonists, ketanserin, pirenperone and LY 53857. Squirrel monkeys responded under a shock titration procedure in which shock intensity increased every 15 s from 0.01 to 2.0 mA
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Global Trade Item Number

SKUGTIN
P126-100MG04061832083575

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