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Merck
CN

P1918

Pancuronium bromide

mAChR blocker, powder

Synonym(s):

1,1′-[(2β,3α,5α,16β,17β)-3,17-bis(Acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide

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About This Item

Empirical Formula (Hill Notation):
C35H60Br2N2O4
CAS Number:
15500-66-0
Molecular Weight:
732.67
NACRES:
NA.77
PubChem Substance ID:
24278623
UNSPSC Code:
12352200
EC Number:
239-532-5
MDL number:
MFCD00079223
Beilstein/REAXYS Number:
4226892
Form:
powder
Quality level:
100

Key Documents

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Product Name

Pancuronium bromide,

form

powder

Quality Level

100

originator

Organon

SMILES string

[Br-].[Br-].[H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@@H](OC(C)=O)[C@H](C[C@@]34[H])[N+]5(C)CCCCC5)[C@@]1(C)C[C@@H]([C@H](C2)OC(C)=O)[N+]6(C)CCCCC6

InChI

1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1

InChI key

NPIJXCQZLFKBMV-YTGGZNJNSA-L

Gene Information

human ... CHRNA1(1134), CHRNB1(1140), CHRND(1144), CHRNE(1145), CHRNG(1146)

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General description

Pancuronium bromide is a biquarternary amino steroid. It blocks muscarinic acetylcholine receptors (M2) in the heart. Pancuronium has vagolytic and sympathomimetic properties. It is associated with tachycardia and hypertension.

Application

Pancuronium Bromide has been used as an analgesic in various experiments.

Biochem/physiol Actions

Aminosteroidal neuromuscular blocking agent; skeletal muscle relaxant

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Organon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN2373
BCCF0176
BCCK7854
BCCH7933
BCCB3719

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Smith and Aitkenhead's Textbook of Anaesthesia E-Book: Expert Consult - Online & Print (2013)
Jing Zhai et al.
American journal of respiratory and critical care medicine, 199(3), 302-312 (2018-12-14)
CC16 (club cell secretory protein-16), a member of the secretoglobin family, is one of the most abundant proteins in normal airway secretions and has been described as a serum biomarker for obstructive lung diseases. To determine whether low CC16 is
Raphaël Candelier et al.
Scientific reports, 5, 12196-12196 (2015-07-22)
Zebrafish larva is a unique model for whole-brain functional imaging and to study sensory-motor integration in the vertebrate brain. To take full advantage of this system, one needs to design sensory environments that can mimic the complex spatiotemporal stimulus patterns
Fluid osmolarity acutely and differentially modulates lymphatic vessels intrinsic contractions and lymph flow
Solari E, et al.
Frontiers in physiology, 9, 871-871 (2018)
Alexandria N Hughes et al.
Nature communications, 10(1), 4125-4125 (2019-09-13)
Vesicular release from neurons promotes myelin sheath growth on axons. Oligodendrocytes express proteins that allow dendrites to respond to vesicular release at synapses, suggesting that axon-myelin contacts use similar communication mechanisms as synapses to form myelin sheaths. To test this
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Articles

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Global Trade Item Number

SKUGTIN
P1918-250MG04061832092591
P1918-50MG04061832092607
P1918-100MG04061832092577
P1918-10MG04061834357155

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