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Merck
CN

PZ0174

Sonepiprazole hydrate

≥98% (HPLC)

Synonym(s):

4-[4-[2-[(1S)-Isochroman-1-yl]ethyl]piperazin-1-yl]benzenesulfonamide hydrate, PNU-101387, PNU-101387G, U-101387

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About This Item

Empirical Formula (Hill Notation):
C21H27N3O3S · xH2O
CAS Number:
170858-33-0
Molecular Weight:
401.52 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
329823748
UNSPSC Code:
51111800
MDL number:
MFCD05662325
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

room temp

SMILES string

NS(=O)(=O)c1ccc(cc1)N2CCN(CC[C@@H]3OCCc4ccccc34)CC2

InChI

1S/C21H27N3O3S/c22-28(25,26)19-7-5-18(6-8-19)24-14-12-23(13-15-24)11-9-21-20-4-2-1-3-17(20)10-16-27-21/h1-8,21H,9-16H2,(H2,22,25,26)/t21-/m0/s1

InChI key

WNUQCGWXPNGORO-NRFANRHFSA-N

Biochem/physiol Actions

Sonepiprazole (U-101387) is a selective D4 dopamine antagonist.
Sonepiprazole (U-101387) is a selective D4 dopamine antagonist. Ki = 10 nM for the dopamine D4.2 receptor.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000164363
0000164363
0000035601
021M4731V

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Mark H Corrigan et al.
Biological psychiatry, 55(5), 445-451 (2004-03-17)
Selective localization of dopamine D(4) receptors in the prefrontal cortex and preferential affinity of clozapine for the dopamine D(4) receptor over the D(2) receptor led to the hypothesis that the superior efficacy of clozapine may be mediated via blockade of
A F Arnsten et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 23(4), 405-410 (2000-09-16)
Stress exposure impairs the cognitive functioning of the prefrontal cortex (PFC). Previous research has examined the dopamine (DA) D1 receptor mechanisms underlying this response. The current study performed a preliminary examination of the role of D4 receptor mechanisms by determining
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.
R E TenBrink et al.
Journal of medicinal chemistry, 39(13), 2435-2437 (1996-06-21)
K Noda-Saita et al.
Biochemical and biophysical research communications, 255(2), 367-370 (1999-03-02)
Dopamine D4-like binding sites are abundant in human cerebral cortex as detected by [3H]nemonapride. The extremely low density of D4 mRNA in human cerebral cortex is inconsistent with the high amount of D4-like binding sites. To investigate the nature of
Peter Hertel et al.
European journal of pharmacology, 573(1-3), 148-160 (2007-08-11)
The present study describes the pharmacological profile of the putative antipsychotic drug Lu 35-138 ((+)-(S)-3-{1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-3,6-dihydro-2H-pyridin-4-yl}-6-chloro-1H-indole). The in vitro receptor profile of Lu 35-138 revealed high affinity (K(i)=5 nM) and competitive antagonism (K(b)=8 nM) at dopamine D(4) receptors combined with potent
View All Related Papers

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Global Trade Item Number

SKUGTIN
PZ0174-25MG04061832083964
PZ0174-5MG04061832083971

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