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Merck
CN

Q0875

Quinidine sulfate salt dihydrate

potassium channel blocker

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About This Item

Empirical Formula (Hill Notation):
C40H48N4O4 · H2O4S · 2H2O
CAS Number:
6591-63-5
Molecular Weight:
782.94
NACRES:
NA.77
PubChem Substance ID:
24277870
UNSPSC Code:
12352200
EC Number:
200-046-3
MDL number:
MFCD00149346
Quality level:
200

Key Documents

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Product Name

Quinidine sulfate salt dihydrate,

Quality Level

200

impurities

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

mp

212-214 °C (dec.) (lit.)

originator

Bayer

SMILES string

[H]O[H].[H]O[H].OS(O)(=O)=O.[H][C@]1(CN2CCC1C[C@]2([H])[C@@H](O)c3ccnc4ccc(OC)cc34)C=C.[H][C@]5(CN6CCC5C[C@]6([H])[C@@H](O)c7ccnc8ccc(OC)cc78)C=C

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1

InChI key

ZHNFLHYOFXQIOW-WFTMRWCJSA-N

Related Categories

General description

Quinidine is an alkaloid present in the bark of the Cinchona tree. It is the D-isomer of quinine, an antimalarial drug.

Application

Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.

Biochem/physiol Actions

Class IA antiarrhythmic; potassium channel blocker.
Quinidine shows therapeutic effects against atrial fibrillation and cardiac arrhythmias.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB6895
0000362976
0000362978
0000434159
0000434159

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Jose Vicente et al.
Journal of the American Heart Association, 4(4) (2015-04-15)
Congenital long QT syndrome type 2 (abnormal hERG potassium channel) patients can develop flat, asymmetric, and notched T waves. Similar observations have been made with a limited number of hERG-blocking drugs. However, it is not known how additional calcium or
Motoya Suzuki et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(11), 1039-1045 (2014-05-21)
1.  This study was aimed to characterize gastrointestinal absorption of digoxin using wild-type (WT) and multidrug resistance protein 1a [mdr1a; P-glycoprotein (P-gp)] knockout (-/-) rats. 2.  In WT rats, the area under the plasma concentration-time curve (AUC) of oral digoxin
Yuki Ogawa et al.
European journal of pediatrics, 174(4), 509-518 (2014-09-25)
This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONMEM). Estimates generated by NONMEM indicated
Maria Addolorata Saracino et al.
Journal of pharmaceutical and biomedical analysis, 95, 61-67 (2014-03-19)
A rapid and reliable analytical method has been developed to quantify the melatonergic antidepressant agomelatine in three matrices, and namely saliva, plasma and dried blood spots. The method is based on the use of liquid chromatography with fluorimetric detection exploiting
Aleksandra Kasperczyk et al.
Magnesium research, 28(1), 14-22 (2015-05-15)
The present study investigated associations between environmental exposure to magnesium (Mg) and the levels of oxidative stress parameters and selected cytokines, and the antioxidant defense system in the seminal plasma of fertile males. The study population consisted of 57 healthy
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Global Trade Item Number

SKUGTIN
Q0875-50G04061832575643
Q0875-25G04061832575636
Q0875-10G04061836687687

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