R104
Rauwolscine hydrochloride
powder
Synonym(s):
α-Yohimbine hydrochloride, 17α-Hydroxy-20α-yohimban-16 β-carboxylic acid methyl ester hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C21H26N2O3 · HCl
CAS Number:
Molecular Weight:
390.90
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
228-279-6
MDL number:
form
powder
optical activity
[α]25/D +52.13°, c = 1 in H2O
color
white to off-white
solubility
H2O: soluble
SMILES string
Cl.COC(=O)[C@@H]1[C@@H](O)CCC2CN3CCc4c([nH]c5ccccc45)C3CC12
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), HTR1A(3350)
Biochem/physiol Actions
α2-adrenoceptor antagonist; 5-HT1A serotonin receptor agonist.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
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B D Perry et al.
European journal of pharmacology, 76(4), 461-464 (1981-12-17)
[3H]Rauwolscine, a specific and potent alpha 2-antagonist radioligand, was used to characterize alpha 2-receptor binding in bovine cerebral cortex. [3H]Rauwolscine binding was reversible, stereospecific, and saturable. Association, dissociation, and saturation studies revealed one site interactions (k -1/k+1 = 1.2 nM
H De Vos et al.
European journal of pharmacology, 207(1), 1-8 (1991-05-25)
The alpha 2 adrenergic antagonist [3H]rauwolscine binds with comparable nanomolar affinity to alpha 2 adrenoceptors and the nonadrenergic 5-HT1A receptors sites in human frontal cortex membranes. Addition of 0.5 mM GTP into the incubation medium produces a significant decrease in
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were