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R137

Ro 31-0432

solid

Synonym(s):

3-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methylindol-3-yl)maleimide hydrochloride, 3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride, Bisindoylmaleimide XI

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About This Item

Empirical Formula (Hill Notation):
C28H28N4O2 · HCl
CAS Number:
145333-02-4
Molecular Weight:
489.01
UNSPSC Code:
12352200
PubChem Substance ID:
329824001
NACRES:
NA.77
Assay:
≥98% (TLC)
Form:
solid
Storage condition:
protect from light
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biological source

synthetic (organic)

assay

≥98% (TLC)

form

solid

storage condition

protect from light

color

orange

solubility

DMSO: 5 mg/mL, H2O: insoluble

storage temp.

−20°C

SMILES string

Cl.CN(C)CC1CCn2c(C1)c(C3=C(C(=O)NC3=O)c4cn(C)c5ccccc45)c6ccccc26

InChI

1S/C28H28N4O2.ClH/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21;/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34);1H

InChI key

HSPRASOZRZDELU-UHFFFAOYSA-N

Biochem/physiol Actions

Protein kinase C (PKC) inhibitor; membrane-derived PKC inhibitor.

Features and Benefits

This compound is featured on the GRKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Photosensitive

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBQ0682V
SLBG3927V
SLBF3164V
SLBB3860V
081M1135V

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S E Wilkinson et al.
The Biochemical journal, 294 ( Pt 2), 335-337 (1993-09-01)
The protein kinase C (PKC) family of isoenzymes is believed to mediate a wide range of signal-transduction pathways in many different cell types. A series of bisindolylmaleimides have been evaluated as inhibitors of members of the conventional PKC family (PKCs-alpha
D Gozal et al.
Journal of applied physiology (Bethesda, Md. : 1985), 84(2), 641-648 (1998-02-26)
Although protein kinase C (PKC) is an essential component of multiple neurally mediated events, its role in respiratory control remains undefined. The ventilatory effects of a systemically active PKC inhibitor (Ro-32-0432; 100 mg/kg i.p.) were assessed by whole body plethysmography
Inhibition of PTH desensitization by inhibition of the G protein-coupled receptor kinase-5 enzyme with Ro 32-0432.
Moore, J.B., et al.
Faseb Journal, 12, A741-A741 (1998)
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Global Trade Item Number

SKUGTIN
R137-1MG04061826132272
R137-5MG04061832449630