R140
Ro 04-6790 dihydrochloride
solid
Synonym(s):
4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide dihydrobromide
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About This Item
Empirical Formula (Hill Notation):
C12H16N6O2S · 2HCl
CAS Number:
Molecular Weight:
381.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Form:
solid
InChI
1S/C12H16N6O2S.2ClH/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9;;/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18);2*1H
SMILES string
Cl.Cl.CNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(NC)n1
InChI key
QOAXXMSJHQHSFV-UHFFFAOYSA-N
form
solid
color
white
solubility
DMSO: >10 mg/mL, H2O: >10 mg/mL
originator
Roche
Gene Information
human ... HTR6(3362)
Biochem/physiol Actions
Selective 5-HT6 serotonin receptor antagonist.
Features and Benefits
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Manufactured and sold under license from Hoffman LaRoche.
Disclaimer
Photosensitive
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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J C Bentley et al.
British journal of pharmacology, 126(7), 1537-1542 (1999-05-14)
1. The present study examined the effects of the selective 5-HT6 receptor antagonist 4-amino-N-(2, 6 bis-methylamino-pyrimidin-4-yl)-benzene sulphonamide (Ro 04-6790) on locomotor activity and unconditioned behaviour in male Sprague Dawley rats (230-300 g). 2. In non-quantified behavioural observations, animals treated with
A J Sleight et al.
British journal of pharmacology, 124(3), 556-562 (1998-07-01)
1. This study describes the in vitro characterization of two potent and selective 5-HT6 receptor antagonists at the rat and human recombinant 5-HT6 receptor. 2. In binding assays with [3H]-LSD, 4-amino-N-(2,6 bis-methylamino-pyrimidin-4-yl)-benzene sulphonamide (Ro 04-6790) and 4-amino-N-(2,6 bis-methylamino-pyridin-4-yl)-benzene sulphonamide (Ro
Bofan Yu et al.
Cell cycle (Georgetown, Tex.), 18(20), 2641-2650 (2019-08-15)
Noncoding RNAs play important roles in the progression of malignant tumors, including triple negative breast cancer (TNBC). Accumulating evidence supported the involvement of the oncogenic MUC1 in tumor metastasis. Our study aimed to explore the roles of miR-140-5p and MUC1
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