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SAB3500536

Anti-HVCN1 antibody produced in rabbit

Name: Anti-HVCN1 antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-HV1, Anti-Hydrogen voltage-gated channel 1, Anti-VSOP, Anti-Voltage sensor domain-only protein

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, WB

Citations:

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Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 30 kDa

species reactivity

rat, human, mouse

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

NCBI accession no.

NP_115745

UniProt accession no.

Q96D96

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HVCN1(84329)

Description

General description

Hydrogen voltage gated channel 1 (HVCN1) is a voltage gated proton channel and is needed for efflux of intracellular acid. The gene encoding it is localized on human chromosome 12q24.11.

Immunogen

HVCN1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human HVCN1.

Biochem/physiol Actions

Hydrogen voltage gated channel 1 (HVCN1) modulates insulin secretion by participating in Ca²⁺ homeostasis. In mice, the channel is involved in superoxide generation, bacterial removal from granulocytes and neutrophils and superoxide-associated B-cell receptor (BCR) signaling. HVCN1 might be associated with BCR-mediated B-cell malignancies.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500536.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品

低风险生物材料

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Certificates of Analysis (COA)

Lot/Batch Number

58762204

58751404

58751003

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The voltage-gated proton channel Hv1 is expressed in pancreatic islet ?-cells and regulates insulin secretion.

Zhao Q

Biochemical and Biophysical Research Communications (2015)

Voltage-Gated Proton Channels as Novel Drug Targets: From NADPH Oxidase Regulation to Sperm Biology

Tamara S

Antioxidants & Redox Signaling (2015)

Hv1 proton channel opening is preceded by a voltage-independent transition.

Villalba-Galea CA

Biophysical Journal (2014)

View All Related Papers

Global Trade Item Number

SKU	GTIN
SBP3500536-0.05MG	04061832170169
SAB3500536-100UG	04061837873942