T0410
Tiapride hydrochloride
Synonym(s):
N-[2-(Diethylamino)ethyl]-5-(methylsulfonyl)-o-anisamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C15H24N2O4S · HCl
CAS Number:
Molecular Weight:
364.89
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
256-908-4
MDL number:
storage temp.
2-8°C
SMILES string
Cl.CCN(CC)CCNC(=O)c1cc(ccc1OC)S(C)(=O)=O
InChI
1S/C15H24N2O4S.ClH/c1-5-17(6-2)10-9-16-15(18)13-11-12(22(4,19)20)7-8-14(13)21-3;/h7-8,11H,5-6,9-10H2,1-4H3,(H,16,18);1H
InChI key
OTFDPNXIVHBTKW-UHFFFAOYSA-N
Gene Information
human ... DRD2(1813), DRD3(1814)
Application
Tiapride and inhibitor of nitric oxide synthase were coadministered to mice to study the effect of dopamine D2 transmission in catalepsy.
Biochem/physiol Actions
Tiapride, an atypical neuroleptic agent, antagonizes D2 and D3 dopamine receptors. It exhibits anti-dyskinetic and anxiolytic activities. It is effective in the management of alcohol withdrawal and treatment of tic disease in children.
Storage Class
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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C Eggers et al.
European archives of psychiatry and neurological sciences, 237(4), 223-229 (1988-01-01)
Tiapride, a substituted benzamide derivative, possesses good clinical antidyskinetic properties due to its DA2-blocking activities. It has been shown to be clinically effective in the treatment of tic disease in children. In order to study tiapride's antidyskinetic properties in the
C Cohen et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 566-573 (1997-11-14)
The ability of tiapride, a selective D2/D3 dopamine receptor antagonist, to exert discriminative stimulus control of responding was investigated by training rats to discriminate this drug (30 mg/kg) from saline in a two-lever, food-reinforcement procedure. Acquisition of tiapride discrimination required
M S Lidow et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 939-946 (1997-11-14)
The RNase Protection Assay was used to examine the regulation of D2 and D4 dopamine receptor mRNAs in the cerebral cortex and neostriatum of nonhuman primates after chronic treatment with a wide spectrum of antipsychotic medications (chlorpromazine, clozapine, haloperidol, molindone