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T7154

Tyr-Ile-Gly-Ser-Arg

≥97% (HPLC)

Synonym(s):

Laminin Fragment 929-933

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About This Item

Empirical Formula (Hill Notation):
C26H42N8O8
CAS Number:
110590-64-2
Molecular Weight:
594.66
NACRES:
NA.32
PubChem Substance ID:
24900419
UNSPSC Code:
12352209
MDL number:
MFCD00076472
Form:
powder
Assay:
≥97% (HPLC)
Biological source:
synthetic (organic)
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biological source

synthetic (organic)

Quality Level

200

assay

≥97% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

H2O: soluble 1 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C26H42N8O8/c1-3-14(2)21(34-22(38)17(27)11-15-6-8-16(36)9-7-15)24(40)31-12-20(37)32-19(13-35)23(39)33-18(25(41)42)5-4-10-30-26(28)29/h6-9,14,17-19,21,35-36H,3-5,10-13,27H2,1-2H3,(H,31,40)(H,32,37)(H,33,39)(H,34,38)(H,41,42)(H4,28,29,30)/t14-,17-,18-,19-,21-/m0/s1

InChI key

MWOGMBZGFFZBMK-LJZWMIMPSA-N

Application

Tyr-Ile-Gly-Ser-Arg (YIGSR) can be used at the interface between the conjugated polymer and the tissue for the engineering of tissue interface. The product can also be used to study the role of integrins β1, α6, and α3 in promoting type II epithelial differentiation during lung maturation in the fetus.

Biochem/physiol Actions

Tyr-Ile-Gly-Ser-Arg (YIGSR) is a pentapeptide of the protein laminin that reduces the lung colony formation in mice administered with melanoma cells as well as can block the invasiveness of the cells in vitro. It inhibits the increased expression of endothelial nitric-oxide synthase in primary porcine aortic endothelial cells.
Tyr-Ile-Gly-Ser-Arg is a fragment of domain III of the laminin B1 chain . It is a major receptor binding site in laminin. It competes with laminin for the cell surface receptor. It is an inhibitor of tumor growth and metastasis.

Preparation Note

Tyr-Ile-Gly-Ser-Arg dissolves in water at 1 mg/ml to yield a clear, colorless solution.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
0000481319
0000481319
0000261358
0000261358
SLCN4078

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Articles

Conjugated Polymers for the Engineering of Device/Tissue Interface

Conjugated polymers offer charge transport between inorganic, electrically conducting metals and organic, proton-conducting biological systems.

Related Content

Product Information Sheet - T7154

Product Information Sheet

Yamato Kikkawa et al.
Cell adhesion & migration, 7(1), 150-256 (2012-12-25)
Laminin-111 is a large trimeric basement membrane glycoprotein with many active sites. In particular, four peptides active in tumor malignancy studies have been identified in laminin-111 using a systematic peptide screening method followed by various assays. Two of the peptides
Presenting multiple adhesion ligands on hydrogels for control of PC12 phenotype.
Jae-Won Lee et al.
Journal of controlled release : official journal of the Controlled Release Society, 152 Suppl 1, e219-e220 (2011-12-27)
Kazuyuki Fukushima et al.
Journal of medical and dental sciences, 55(1), 71-79 (2008-03-01)
We developed a honeycomb-shaped lyophilized Type I atelocollagen (Honeycomb Collagen: HC) with different pore sizes, and the effectiveness of the honeycomb shape on nerve regeneration was examined. We analyzed neurite outgrowth of dorsal root ganglion (DRG) explants on HC, both
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Global Trade Item Number

SKUGTIN
T7154-1MG04061826677216
T7154-5MG04061833265789