T8765
Thr-Ser-Lys acetate salt
≥97% (HPLC)
Synonym(s):
Antireproductive tripeptide
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About This Item
Empirical Formula (Hill Notation):
C13H26N4O6
CAS Number:
Molecular Weight:
334.37
UNSPSC Code:
12352200
assay
≥97% (HPLC)
storage temp.
−20°C
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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B Benson
Journal of pineal research, 6(4), 351-357 (1989-01-01)
When injected into rodents, the bovine pineal tripeptide threonylseryllysine (TSL) elicits diverse antireproductive effects in a number of animal models. Extensive studies of its effects on pubertal development have not been carried out, however. In the present study, 1.0 microgram
R S Root-Bernstein et al.
Brain research bulletin, 17(4), 519-528 (1986-10-01)
We report results of chromatographic, pH titration and nuclear magnetic resonance (NMR) spectroscopy studies demonstrating that the bovine pineal antireproductive tripeptide, Thr-Ser-Lys (BPART), binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5 (His-Trp-Ser-Tyr). BPART and LHRH
The pineal gland--a survey of its antigonadotropic substances and their actions.
M K Vaughn
International review of physiology, 24, 41-95 (1981-01-01)
Orts, R.J., et al.
The Physiologist, 21, 87-87 (1978)
R J Orts et al.
Neuroendocrinology, 31(2), 92-95 (1980-08-01)
Administration of the bovine pineal peptide threonylseryllysine (TSL) to unilaterally ovariectomized (UO) mice as a single intraperitoneal injection on the day of UO reduced the 5-day compensatory ovarian hypertrophy. The same dose of TSL (175 ng/animal) significantly (p less than
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