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U0750

Uracil

Name: Uracil
Brand: SIGMA

≥99.0%, synthetic (organic), powder

Synonym(s):

2,4(1H,3H)-Pyrimidinedione, 2,4-Dihydroxypyrimidine, 2,4-Pyrimidinediol

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About This Item

Empirical Formula (Hill Notation):

C₄H₄N₂O₂

CAS Number:

66-22-8

Molecular Weight:

112.09

NACRES:

NA.51

PubChem Substance ID:

24900618

UNSPSC Code:

41106305

EC Number:

200-621-9

MDL number:

MFCD00006016

Beilstein/REAXYS Number:

507828

Assay:

≥99.0%

Biological source:

synthetic (organic)

Form:

powder

Solubility:

1 M NaOH: 50 mg/mL, clear to hazy, colorless to faint yellow or tan

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Product Name

Uracil, ≥99.0%

biological source

synthetic (organic)

Quality Level

300

assay

≥99.0%

form

powder

mp

>300 °C (lit.)

solubility

1 M NaOH: 50 mg/mL, clear to hazy, colorless to faint yellow or tan

SMILES string

O=C1NC=CC(=O)N1

InChI

1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

InChI key

ISAKRJDGNUQOIC-UHFFFAOYSA-N

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Related Categories

Biochemicals

Nucleosides and Nucleotides

General description

Uracil belongs to the pyrimidine nucleobase family. It is naturally occurring and is an important and active part of RNA.

Application

Uracil has been used as:

a nucleotide standard to determine DNA methylation by high-performance liquid chromatography
a component of synthetic define medium for culturing Saccharomyces cerevisiae and its strain
a component of the amino acid supplement to culture Bacillus sp

Biochem/physiol Actions

Uracil and its derivatives play an integral part in medicinal chemistry for the synthesis of cancer, viral infections, autosomal recessive disorder, thyroid, and diabetic drugs.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Comparative metabolite profiling of wild type and thermo-tolerant mutant of Saccharomyces cerevisiae

Kim S, et al.

Process Biochemistry (Oxford, United Kingdom), 111, 62-68 (2021)

Therapeutic potential of uracil and its derivatives in countering pathogenic and physiological disorders.

Deepthi Ramesh et al.

European journal of medicinal chemistry, 207, 112801-112801 (2020-09-15)

Uracil is one of the most notable pharmacophores in medicinal chemistry as the pyrimidine nucleobase forms an integral part of many commercial drugs. Though the name uracil is usually associated with cancer drugs, there are many uracil-based compounds which can

Environmental and nutritional factors that affect growth and metabolism of the pneumococcal serotype 2 strain D39 and its nonencapsulated derivative strain R6.

Sandra M Carvalho et al.

PloS one, 8(3), e58492-e58492 (2013-03-19)

Links between carbohydrate metabolism and virulence in Streptococcus pneumoniae have been recurrently established. To investigate these links further we developed a chemically defined medium (CDM) and standardized growth conditions that allowed for high growth yields of the related pneumococcal strains

ABT-450, ritonavir, ombitasvir, and dasabuvir achieves 97% and 100% sustained virologic response with or without ribavirin in treatment-experienced patients with HCV genotype 1b infection.

Pietro Andreone et al.

Gastroenterology, 147(2), 359-365 (2014-05-14)

The interferon-free regimen of ABT-450 (a protease inhibitor), ritonavir, ombitasvir (an NS5A inhibitor), dasabuvir (a non-nucleoside polymerase inhibitor), and ribavirin has shown efficacy in patients with hepatitis C virus (HCV) genotype 1b infection-the most prevalent subgenotype worldwide. We evaluated whether

Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin.

Jordan J Feld et al.

The New England journal of medicine, 370(17), 1594-1603 (2014-04-12)

The interferon-free combination of the protease inhibitor ABT-450 with ritonavir (ABT-450/r) and the NS5A inhibitor ombitasvir (also known as ABT-267) plus the nonnucleoside polymerase inhibitor dasabuvir (also known as ABT-333) and ribavirin has shown efficacy against the hepatitis C virus

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Global Trade Item Number

SKU	GTIN
U0750-25G	04061835522316
U0750-1KG	04061826746004
U0750-100G	04061837403828
U0750-5G	04061835559428
U0750-500G	04061837403835

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