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A0230

Angiotensin IV trifluoroacetate salt

Name: Angiotensin IV trifluoroacetate salt
Brand: SIGMA

≥95% (HPLC), powder

Synonym(s):

Ang IV, Angiotensin II (3-8)

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About This Item

Empirical Formula (Hill Notation):

C₄₀H₅₄N₈O₈ · xC₂HF₃O₂

CAS Number:

12676-15-2

Molecular Weight:

774.91 (free base basis)

NACRES:

NA.77

PubChem Substance ID:

329770587

UNSPSC Code:

12352200

MDL number:

MFCD00167496

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

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Properties

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white

solubility

H₂O: ~1 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI

1S/C40H54N8O8/c1-5-24(4)34(47-35(50)29(44-37(52)33(41)23(2)3)18-26-13-15-28(49)16-14-26)38(53)45-30(20-27-21-42-22-43-27)39(54)48-17-9-12-32(48)36(51)46-31(40(55)56)19-25-10-7-6-8-11-25/h6-8,10-11,13-16,21-24,29-34,49H,5,9,12,17-20,41H2,1-4H3,(H,42,43)(H,44,52)(H,45,53)(H,46,51)(H,47,50)(H,55,56)/t24-,29-,30-,31-,32-,33-,34-/m0/s1

InChI key

QSBGWDDCOJYQGY-KOQODJNWSA-N

Description

Biochem/physiol Actions

AT₄ angiotensin receptor agonist.

AT₄ angiotensin receptor agonist. The AT₄receptor appears to be important in synaptic plasticity and thus in learning and memory.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Responses of patients with Bartter's syndrome to angiotensin III and angiotensin II-(3-8)-hexapeptide.

T Kono et al.

Acta endocrinologica, 109(2), 249-253 (1985-06-01)

Studies were conducted to determine whether or not angiotensin III [AIII] and angiotensin II-(3-8)-hexapeptide [ANG-(3-8)] have their own specific arteriolar binding sites different from angiotensin II [AII] binding site(s) in man. Four patients with Bartter's syndrome were given asn1-,val5-AII by

Angiotensin IV activates the nuclear transcription factor-kappaB and related proinflammatory genes in vascular smooth muscle cells.

Vanesa Esteban et al.

Circulation research, 96(9), 965-973 (2005-04-16)

Inflammation is a key event in the development of atherosclerosis. Nuclear factor-kappaB (NF-kappaB) is important in the inflammatory response regulation. The effector peptide of the renin angiotensin system Angiotensin II (Ang II) activates NF-kappaB and upregulates some related proinflammatory genes.

Alzheimer's, angiotensin IV and an aminopeptidase.

Anthony Lloyd Albiston et al.

Biological & pharmaceutical bulletin, 27(6), 765-767 (2004-06-10)

The angiotensin AT(4) receptor was originally defined as the specific, high affinity binding site for the hexapeptide angiotensin IV (Ang IV). Subsequently, the peptide LVV-hemorphin 7 was also demonstrated to be a bioactive ligand of the AT(4) receptor. Central administration

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Global Trade Item Number

SKU	GTIN
A0230-1MG	04061833327142