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Merck
CN

A1976

Anti-Amyloid Peptide β, Cleavage Site 42 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Aβ 42

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD04040171
Conjugate:
unconjugated
Clone:
polyclonal
Application:
dot blot
immunoblotting
immunohistochemistry
immunoprecipitation (IP)
indirect ELISA
radioimmunoassay
Species reactivity:
rat, human, mouse
Citations:
3
Technique(s):
dot blot: 0.05-1 μg/mL
immunoblotting: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: 1:200
radioimmunoassay: 1:200
Uniprot accession no.:
P05067

Key Documents

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Product Name

Anti-Amyloid Peptide β, Cleavage Site 42 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 4 kDa

species reactivity

rat, human, mouse

packaging

antibody small pack of 25 μg

technique(s)

dot blot: 0.05-1 μg/mL
immunoblotting: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: 1:200
radioimmunoassay: 1:200

UniProt accession no.

P05067

shipped in

dry ice

storage temp.

−70°C

target post-translational modification

proteolytically cleaved (Ala42)

Quality Level

100

Gene Information

human ... APP(351)
mouse ... App(11820)
rat ... App(54226)

Related Categories

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Rabbit anti-Aβ42 is suitable for use in immunoblot, immunohistochemistry, immunoprecipitation, RIA, ELISA and dot blot applications.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Proteolytic cleavage of the amyloid precursor protein (APP) produces the small fragment amyloid β peptide. Cleavage of APP occurs mostly at residue 40 but to a lesser extent residue 42. Aggregates of amyloid β peptide are found deposited in the brains of Alzheimer′s patients.
Rabbit anti-amyloid peptide β, cleavage site 42 (Aβ42) antibody binds to human, mouse and rat Aβ42.

Immunogen

synthetic peptide of approximately 10 amino acid residues at the C-terminus of Aβ42.

Physical form

Solution in phosphate buffer, pH 7.4, containing approximately 25 μg of antibody.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLCP5602
SLCM0687
SLCL9245
SLCL8261
SLCD4321

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Kathlyn J Gan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(42), 8088-8102 (2020-09-26)
Emerging evidence supports roles for secreted extracellular matrix proteins in boosting synaptogenesis, synaptic transmission, and synaptic plasticity. SPARCL1 (also known as Hevin), a secreted non-neuronal protein, was reported to increase synaptogenesis by simultaneously binding to presynaptic neurexin-1α and to postsynaptic
Ukjin Kim et al.
Frontiers in pharmacology, 10, 1517-1517 (2020-02-06)
The United States Food and Drug Administration-approved antipsychotic drug, pimozide, has anticancer activities. However, the role of reactive oxygen species (ROS) in its effect on prostate cancer is not well-known. We examined cell proliferation, colony formation, migration, ROS production, and
Bao-Xi Qu et al.
Journal of the neurological sciences, 260(1-2), 204-213 (2007-06-19)
Abeta42 peptide aggregation and deposition is an important component of the neuropathology of Alzheimer's disease (AD). Gene-gun mediated gene vaccination targeting Abeta42 is a potential method to prevent and treat AD. APPswe/PS1DeltaE9 transgenic (Tg) mice were immunized with an Abeta42

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