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A255

A-77636 hydrochloride hydrate

Name: A-77636 hydrochloride hydrate
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

(−)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₇NO₃ · HCl · xH₂O

CAS Number:

145307-34-2

Molecular Weight:

365.89 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24277883

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated, protect from light

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Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated, protect from light

color

white to off-white

solubility

H₂O: >10 mg/mL

storage temp.

−20°C

SMILES string

O.Cl.NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)C34CC5CC(CC(C5)C3)C4

InChI

1S/C20H27NO3.ClH.H2O/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H;1H2/t11?,12?,13?,17-,18-,20?;;/m0../s1

InChI key

KNACNUUSUYTFDY-LIWDBWMRSA-N

Gene Information

human ... DRD1(1812)

Biochem/physiol Actions

Potent, orally active D₁ dopamine receptor agonist.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold under exclusive license from Abbott Laboratories.

Disclaimer

Hygroscopic, photosensitive, and oxygen-sensitive. Solutions should be freshly prepared.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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The effect of a full agonist/antagonist of the D1 receptor on locomotor activity, sensorimotor gating and cognitive function in dizocilpine-treated rats.

Vera Bubenikova-Valesova et al.

The international journal of neuropsychopharmacology, 12(7), 873-883 (2009-01-22)

Cognitive impairment has been found across all subtypes of schizophrenia. The location and function of dopamine-1 receptors (D1Rs) make them attractive targets for the treatment of cognitive impairment in schizophrenia. Here we investigate the systemic effect of a D1R agonist

Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions.

Amy F T Arnsten et al.

Biological psychiatry, 57(11), 1377-1384 (2005-06-14)

The prefrontal cortex guides behaviors, thoughts, and feelings using representational knowledge, i.e., working memory. These fundamental cognitive abilities subserve the so-called executive functions: the ability to inhibit inappropriate behaviors and thoughts, regulate our attention, monitor our actions, and plan and

Chronic lithium attenuates dopamine D1-receptor mediated increases in acetylcholine release in rat frontal cortex.

E Acquas et al.

Psychopharmacology, 125(2), 162-167 (1996-05-01)

The effects of chronic lithium treatment on methylphenidate-, D1 dopamine receptor agonist (A-77636)-, and tactile stimulation-induced increases in frontal cortical acetylcholine release were studied in the rat using in vivo brain microdialysis. Cortical acetylcholine release in control rats was maximally

Comparison of interactions of D1-like agonists, SKF 81297, SKF 82958 and A-77636, with cocaine: locomotor activity and drug discrimination studies in rodents.

Allison L Chausmer et al.

Psychopharmacology, 159(2), 145-153 (2002-02-28)

Recent data suggest that dopamine (DA) D1-like receptor full agonists may be potential pharmacotherapeutic agents for treating cocaine abuse. The structurally novel isochroman D1-like agonist, A-77636, has not been well characterized and may prove to be useful as such an

Negative feedback regulation of nigrostriatal dopamine release: mediation by striatal D1 receptors.

Sanjida S Saklayen et al.

The Journal of pharmacology and experimental therapeutics, 311(1), 342-348 (2004-06-04)

The nigrostriatal dopamine system of the mammalian brain is necessary for normal voluntary motor activity. Dopamine exerts its effects by acting on two primary receptor subtypes: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptors. Previous research has

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Global Trade Item Number

SKU	GTIN
A255-100MG	04061832079134
A255-10MG	04061832079141

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