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A2900

[Val⁵]-Angiotensin II acetate salt hydrate

Name: [Val<SUP>5</SUP>]-Angiotensin II acetate salt hydrate
Brand: SIGMA

≥95% (HPLC), angiotensin II type 1 receptor agonist, powder

Synonym(s):

Angiotensin II Acetate

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About This Item

Empirical Formula (Hill Notation):

C₄₉H₆₉N₁₃O₁₂ · xC₂H₄O₂ · yH₂O

Molecular Weight:

1032.15 (anhydrous free base basis)

UNSPSC Code:

12352209

PubChem Substance ID:

329770803

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

powder

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Properties

Product Name

[Val⁵]-Angiotensin II acetate salt hydrate, ≥95% (HPLC), powder

Quality Segment

200

assay

≥95% (HPLC)

form

powder

composition

acetate, 1.2-10.4%

storage temp.

−20°C

SMILES string

O.CC(O)=O.CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI

1S/C49H69N13O12.C2H4O2.H2O/c1-26(2)39(60-42(67)33(12-8-18-54-49(51)52)56-41(66)32(50)23-38(64)65)45(70)57-34(20-29-14-16-31(63)17-15-29)43(68)61-40(27(3)4)46(71)58-35(22-30-24-53-25-55-30)47(72)62-19-9-13-37(62)44(69)59-36(48(73)74)21-28-10-6-5-7-11-28;1-2(3)4;/h5-7,10-11,14-17,24-27,32-37,39-40,63H,8-9,12-13,18-23,50H2,1-4H3,(H,53,55)(H,56,66)(H,57,70)(H,58,71)(H,59,69)(H,60,67)(H,61,68)(H,64,65)(H,73,74)(H4,51,52,54);1H3,(H,3,4);1H2/t32-,33-,34-,35-,36-,37-,39-,40-;;/m0../s1

InChI key

INQPQDZJLFYCRH-AXOAQIBVSA-N

Gene Information

human ... AGTR1(185)
mouse ... AGTR1(11607)
rat ... AGTR1(24180)

Description

General description

[Val5]-Angiotensin II ([Val5]-ANG II) is an ANG II analog containing valine as the fifth amino acid in place of isoleucine in an ANG II octapeptide.

Application

[Val5]-Angiotensin II acetate salt hydrate has been used to induce:

renal damage in mice to study the role of human liver-type fatty acid-binding protein (hL-FABP)
vascular inflammation in mice to study the interaction of cytosolic copper chaperone antioxidant-1 (Atox1) with tumor necrosis factor (TNF)-receptor-associated factor 4 (TRAF4)
abdominal aortic aneurysm (AAA) in mice to study the role of vascular ATPase copper transporting α (ATP7α)

Biochem/physiol Actions

[Val5]-Angiotensin II acts as an agonist for the angiotensin II type 1 receptor (AT1 receptor).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

0000481317

0000443459

0000441480

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Global Trade Item Number

SKU	GTIN
A2900-10MG	04061832268972
A2900-50MG	04061832674209
A2900-1MG	04061823010900
A2900-5MG	04061832674223