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Merck
CN

A3481

Anti-ApoER2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Apolipoprotein E Receptor 2, Anti-LRP8, Anti-Low Density Lipoprotein Receptor-Related Protein 8

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-ApoER2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~105 kDa

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

technique(s)

western blot: 0.5-1 μg/mL using HEK-293T cells expressing human ApoER2

UniProt accession no.

Q14114

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... LRP8(7804)

Related Categories

Application

Anti-ApoER2 antibody produced in rabbit has been used in western blot analysis.

Biochem/physiol Actions

Apolipoprotein E receptor 2 (ApoER2, also known as LRP8) play an important role in the endocytosis of plasma lipoproteins, including ApoE and cholesterol metabolism. In the central nervous system, ApoER2 mediates various neuronal signaling mechanisms during neuronal development, affecting neurite outgrowth, synapse formation and neuronal migration, and neuronal survival in response to acute damage. ApoER2 plays a central role in the reelin/Dab1 signaling pathway that controls neuronal positioning during brain development as well as long-term potentiation (LTP) in the adult brain.
Rabbit anti-ApoER2 antibody recognizes human ApoER2 by immunoblotting (approx. 105kDa). Staining of the ApoER2 band in immunoblotting is specifically inhibited by the ApoER2 immunizing peptide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Apolipoprotein E receptor 2 (ApoER2, also known as LRP8) is expressed predominantly in the brain and placenta. This gene is located on human chromosome 1p32.
The low-density lipoprotein receptor-related protein 8 (LRP8) or ApoER2 is a member of the LDL receptor family which includes LDLR and VLDLR. These proteins are involved in the uptake of lipid rich proteins into cells and cell signaling. ApoER2 assists in endocytosis and signal transduction.

Immunogen

synthetic peptide corresponding to amino acids 928-945 located near the C-terminus of human ApoER2, conjugated to KLH. This sequence is identical in mouse ApoER2.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000218072
0000218072
0000185650
54070203
0000185650

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Structural basis for ligand capture and release by the endocytic receptor ApoER2
Hirai H, et al.
EMBO Reports, 18(6), 982-999 (2017)
Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2
Beffert U, et al.
Neuron, 47(4), 567-579 (2005)
The reelin receptors apolipoprotein E receptor 2 (ApoER2) and VLDL receptor
Dlugosz P and Nimpf J
International Journal of Molecular Sciences, 19(10), 3090-3090 (2018)
Further evidence for the association between LRP8 and schizophrenia
Xiao X, et al.
Schizophrenia Research (2017)
Ignacio Jausoro et al.
Journal of neuroscience research, 99(1), 392-406 (2020-07-12)
Axonal outgrowth is a fundamental process during the development of central (CNS) and peripheral (PNS) nervous system as well as in nerve regeneration and requires accurate axonal navigation and extension to the correct target. These events need proper coordination between
View All Related Papers

Related Content

Data Sheet - A3481

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