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Merck
CN

A5111

ABT-724 trihydrochloride

≥98% (HPLC)

Synonym(s):

2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole trihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H19N5 · 3HCl
CAS Number:
587870-77-7
Molecular Weight:
402.75
NACRES:
NA.77
PubChem Substance ID:
329770868
UNSPSC Code:
12352202
MDL number:
MFCD08703101
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

Key Documents

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Product Name

ABT-724 trihydrochloride, ≥98% (HPLC)

InChI

1S/C17H19N5.3ClH/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17;;;/h1-8H,9-13H2,(H,19,20);3*1H

SMILES string

Cl.Cl.Cl.C1CN(CCN1Cc2nc3ccccc3[nH]2)c4ccccn4

InChI key

AZFUVPBLKQGSRI-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

H2O: >30 mg/mL

originator

Abbott

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

ABT-724 is a dopamine D4 receptor agonist. ABT-724 has been used in the study of impulsive behavior and penile erection in rats.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

wgk

WGK 3

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000392810
0000392810
089K4701V
089K4701

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Ronan Depoortère et al.
Behavioural pharmacology, 20(4), 303-311 (2009-07-09)
Dopamine (DA) is implicated in penile erection (PE) and yawning (YA) in rats through activation of D2-like receptors. However, the exact role of each subtype (D2, D3 and D4) of this receptor family in PE/YA is still not clearly elucidated.
Mikhail N Koffarnus et al.
Behavioural pharmacology, 22(4), 300-311 (2011-06-23)
Impulsivity is widely regarded as a multidimensional trait that encompasses two or more distinct patterns of behavior, and dopaminergic systems are implicated in the expression of impulsive behavior in both humans and animal subjects. Impulsive choice, or the tendency to
Danuta Marona-Lewicka et al.
Psychopharmacology, 203(2), 265-277 (2008-07-08)
Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. The present study sought to characterize the effects of several dopamine D(4) agonists

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