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A6428

Aflatoxin M₁

Name: Aflatoxin M<SUB>1</SUB>
Brand: SIGMA

From Aspergillus flavus, , mycotoxin, film

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₂O₇

CAS Number:

6795-23-9

Molecular Weight:

328.27

NACRES:

NA.77

PubChem Substance ID:

24891088

UNSPSC Code:

12352200

EC Number:

229-865-4

MDL number:

MFCD00871812

Form:

film

Quality level:

200

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Product Name

Aflatoxin M₁, from Aspergillus flavus

biological source

Aspergillus flavus

Quality Level

200

form

film

storage temp.

2-8°C

SMILES string

[H][C@]12OC=C[C@@]1(O)c3c(O2)cc(OC)c4C5=C(C(=O)CC5)C(=O)Oc34

InChI

1S/C17H12O7/c1-21-9-6-10-13(17(20)4-5-22-16(17)23-10)14-12(9)7-2-3-8(18)11(7)15(19)24-14/h4-6,16,20H,2-3H2,1H3/t16-,17-/m1/s1

InChI key

MJBWDEQAUQTVKK-IAGOWNOFSA-N

Related Categories

Bioactive Small Molecule Toxins

Bioactive Small Molecules

General description

Aflatoxins are metabolites of fungus, that are mainly seen in feeds and foods. Aflatoxin M₁ is a hydroxylated metabolite of aflatoxin B₁. It is liberated in milk, urine and produced in liver after receiving aflatoxin B₁.

Application

Aflatoxin M1 has been used as a standard to investigate the incidence and occurrence of aflatoxin M₁ (AFM₁) in Brazilian milk and infant formula. It has also been used as standard to investigate the incidence and occurrence of aflatoxin M1 (AFM₁) in dairy products produced in Brazil.

Aflatoxin M1 is both a hepatotoxic and hepatocarcinogenic mycotoxin that has been shown to cause immunosuppression in animals.

Biochem/physiol Actions

Aflatoxin M1 possesses hepatocarcinogenic properties.

Preparation Note

Aspergillus flavus metabolite.

Disclaimer

Possibly carcinogenic.

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300 + H310 + H330,H340,H350

pcodes

P202 - P260 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Carc. 1B - Muta. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Aflatoxins

Handbook of Secondary Fungal Metabolites, 545-569 (2003)

Development of an electrochemical biosensor for the detection of aflatoxin M1 in milk.

Nathalie Paniel et al.

Sensors (Basel, Switzerland), 10(10), 9439-9448 (2010-01-01)

We have developed an electrochemical immunosensor for the detection of ultratrace amounts of aflatoxin M(1) (AFM(1)) in food products. The sensor was based on a competitive immunoassay using horseradish peroxidase (HRP) as a tag. Magnetic nanoparticles coated with antibody (anti-AFM(1))

Aflatoxin M1 in milk and distribution and stability of aflatoxin M1 during production and storage of yoghurt and cheese

Iha MH, et al.

Food Control, 29(1), 1-6 (2013)

Aflatoxins

Handbook of Secondary Fungal Metabolites (2003)

Occurrence of aflatoxin M1 in dairy products in Brazil