A7980
AC-41848 hydrate
≥98% (HPLC), solid
Synonym(s):
1-[(2,4-Dichlorophenyl)methyl]-6,7,8,9-tetrahydro-3-phenyl-5H-imidazo[1,2-a]azepinium bromide hydrate
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About This Item
Empirical Formula (Hill Notation):
C21H21BrCl2N2 · xH2O
CAS Number:
Molecular Weight:
452.21 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, under inert gas
Quality Segment
assay
≥98% (HPLC)
form
solid
storage condition
desiccated, under inert gas
solubility
DMSO: ~14 mg/mL, H2O: >5 mg/mL
storage temp.
2-8°C
SMILES string
[Br-].[H]O[H].Clc1ccc(C[n+]2cc(-c3ccccc3)n4CCCCCc24)c(Cl)c1
InChI
1S/C21H21Cl2N2.BrH.H2O/c22-18-11-10-17(19(23)13-18)14-24-15-20(16-7-3-1-4-8-16)25-12-6-2-5-9-21(24)25;;/h1,3-4,7-8,10-11,13,15H,2,5-6,9,12,14H2;1H;1H2/q+1;;/p-1
InChI key
FPOBEBBUBSFIIA-UHFFFAOYSA-M
Application
AC-41848 is a potent, cell permeable, and subtype selective retinoic acid receptor RARγ agonist.
Biochem/physiol Actions
AC-41848 is a potent, cell permeable, subtype selective retinoic acid receptor RARγ agonist. AC-41848 has high selectivity (92%) for RARγ. EC50 = 5.9 μM.
Potent, cell permeable, subtype selective retinoic acid receptor RARγ agonist. High selectivity (92%) for RARγ. EC50 = 5.9 μM.
Features and Benefits
This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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