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A9719

Arachidonyl-2′-chloroethylamide hydrate

Name: Arachidonyl-2′-chloroethylamide hydrate
Brand: SIGMA

≥97% (HPLC), oil

Synonym(s):

ACEA

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₃₆ClNO · xH₂O

CAS Number:

220556-69-4

Molecular Weight:

365.98 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

24891489

UNSPSC Code:

51111800

MDL number:

MFCD02683581

Assay:

≥97% (HPLC)

Form:

oil

Quality level:

100

Storage condition:

desiccated

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Quality Level

100

assay

≥97% (HPLC)

form

oil

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

storage condition

desiccated

color

brown-red

solubility

DMSO: soluble, H₂O: insoluble

storage temp.

−20°C

SMILES string

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCCl

InChI

1S/C22H36ClNO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)24-21-20-23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,24,25)/b7-6-,10-9-,13-12-,16-15-

InChI key

SCJNCDSAIRBRIA-DOFZRALJSA-N

Gene Information

mouse ... Cnr1(12801), Cnr2(12802)
rat ... Cnr1(25248)

Related Categories

Bioactive Small Molecule Agonists

Biochem/physiol Actions

Potent and selective neuronal CB₁ cannabinoid receptor agonist.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Photosensitive; store under argon or nitrogen.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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An Intraplantar Hypertonic Saline Assay in Mice for Rapid Screening of Analgesics.

Yahya I Asiri et al.

Anesthesia and analgesia, 127(2), 548-555 (2017-10-11)

Development of new analgesics is limited by shortcomings of existing preclinical screening assays such as wide variations in response, suitability for a narrow range of analgesics, and propensity to induce tissue damage. Our aim was to determine the feasibility of

Somatostatin Analogue Treatment Primarily Induce miRNA Expression Changes and Up-Regulates Growth Inhibitory miR-7 and miR-148a in Neuroendocrine Cells.

Kristina B V Døssing et al.

Genes, 9(7) (2018-07-06)

Somatostatin (SST) analogues are used to control the proliferation and symptoms of neuroendocrine tumors (NETs). MicroRNAs (miRNA) are small non-coding RNAs that modulate posttranscriptional gene expression. We wanted to characterize the miRNAs operating under the control of SST to elucidate

Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells.

Akiko Tsuchida et al.

Scientific reports, 8(1), 7017-7017 (2018-05-08)

GalNAc-disialyl Lc4 (GalNAc-DSLc4) was reported as a novel antigen that associated with malignant features of renal cell cancers (RCCs). To clarify roles of GalNAc-DSLc4 in malignant properties of RCCs, we identified B4GalNAc-T2 as a responsible gene for the synthesis of

The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints.

Chris L Baker et al.

British journal of pharmacology, 142(8), 1361-1367 (2004-07-28)

The vasoactive effects of the synthetic cannabinoid (CB) arachidonyl-2-chloroethylamide (ACEA) was tested in the knee joints of urethane-anaesthetised rats. Experiments were also performed to determine whether these vasomotor responses could be blocked by the selective CB(1) receptor antagonists AM251 (N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide)

Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).

C J Hillard et al.

The Journal of pharmacology and experimental therapeutics, 289(3), 1427-1433 (1999-05-21)

Two subtypes of the cannabinoid receptor (CB1 and CB2) are expressed in mammalian tissues. Although selective antagonists are available for each of the subtypes, most of the available cannabinoid agonists bind to both CB1 and CB2 with similar affinities. We

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Global Trade Item Number

SKU	GTIN
A9719-25MG	04061833412244

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