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AV33672

Sigma-Aldrich

Anti-NR1H4 antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Anti-Nuclear receptor subfamily 1, group H, member 4
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

54 kDa

species reactivity

guinea pig, horse, bovine, rat, human, mouse, dog

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_005114

UniProt accession no.

Q96RI1-2

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NR1H4(9971)

General description

Farnesoid X receptor (FXR/NR1H4) belongs to the nuclear receptor (NR) superfamily. It is a receptor of bile acids (BAs). FXR is expressed in liver, intestine, kidney and adrenal gland. This gene is located on human chromosome 12q23. It has n N-terminal DNA binding domain (DBD) and the C-terminal ligand binding domain (LBD).

Immunogen

Synthetic peptide directed towards the middle region of human NR1H4

Biochem/physiol Actions

The NR1H4 gene encodes a protein that has a central role in lipid homeostasis and also regulates carbohydrate metabolism.
The ligand-activated transcription factor farnesoid X receptor (FXR/NR1H4) plays a key role in metabolic regulation and liver protection. FXR modulates bile acid, lipid and glucose metabolism. It participates in the modulation of bile acid synthesis, secretion and transport. Mutation in this gene results in familial intrahepatic cholestasis.

Sequence

Synthetic peptide located within the following region: AECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKT

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Molecular tuning of farnesoid X receptor partial agonism
Merk D, et al.
Nature Communications, 10 (2019)
Update on FXR Biology: Promising Therapeutic Target
Han CY
International Journal of Molecular Sciences, 19(7) (2018)
NR1H4 (nuclear receptor subfamily 1, group H, member 4)
Briz O, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2014)
Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis
Gomez- ON, et al.
Nature Communications, 7(10713), 1-8 (2016)

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