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Merck
CN

AV49411

Anti-HLA-F antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CDA12, Anti-HLA-5.4, Anti-HLA-CDA12, Anti-HLAF, Anti-Major histocompatibility complex, class I, F

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Species reactivity:
pig, human
Conjugate:
unconjugated
Application:
IHC, WB
Citations:
2

Key Documents

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species reactivity

pig, human

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

48 kDa

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable, western blot: suitable

NCBI accession no.

NP_061823

UniProt accession no.

P30511

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Gene Information

human ... HLA-F(3134)

Related Categories

Immunogen

Synthetic peptide directed towards the N terminal region of human HLA-F

Application

Anti-HLA-F antibody produced in rabbit is suitable for western blotting at a concentration of 1.0μg/ml.

Biochem/physiol Actions

Major histocompatibility complex, class I, F (HLA-F) is a non-classic heavy chain that forms a heterodimer with β-2 microglobulin and participates in MHC-I antigen cross-presentation pathway. HLA-F functions as a ligand for Ig-like receptors on natural killer cells that regulate the inflammatory response.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Other Notes

Synthetic peptide located within the following region: EAGSHTLQGMNGCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADT

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC20702

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Jodie P Goodridge et al.
Journal of immunology (Baltimore, Md. : 1950), 191(7), 3553-3562 (2013-09-11)
Killer Ig-like receptors (KIRs) are innate immune receptors expressed by NK and T cells classically associated with the detection of missing self through loss of their respective MHC ligand. Some KIR specificities for allelic classical class I MHC (MHC-I) have
Jodie P Goodridge et al.
Journal of immunology (Baltimore, Md. : 1950), 191(4), 1567-1577 (2013-07-16)
Peptides that are presented by MHC class I (MHC-I) are processed from two potential sources, as follows: newly synthesized endogenous proteins for direct presentation on the surface of most nucleated cells and exogenous proteins for cross-presentation typically by professional APCs.

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