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B169

BRL 37344 sodium salt hydrate

Name: BRL 37344 sodium salt hydrate
Brand: SIGMA

≥98% (HPLC), β3-adrenergic receptor agonist, solid

Synonym(s):

(±)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetic acid sodium hydrate, BRL 37344A

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₁ClNNaO₄ · xH₂O

CAS Number:

127299-93-8

Molecular Weight:

385.82 (anhydrous basis)

MDL number:

MFCD09971030

UNSPSC Code:

12352200

PubChem Substance ID:

24277764

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Product Name

BRL 37344 sodium salt hydrate, solid

assay

≥98% (HPLC)

Quality Level

100

form

solid

color

white

solubility

DMSO: 18 mg/mL, clear (warmed)

SMILES string

O.[Na+].C[C@H](Cc1ccc(OCC([O-])=O)cc1)NC[C@H](O)c2cccc(Cl)c2

InChI

1S/C19H22ClNO4.Na.H2O/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24;;/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24);;1H2/q;+1;/p-1/t13-,18+;;/m1../s1

InChI key

YTPAKDODIXRQTF-BNTHFPBMSA-M

Gene Information

human ... ADRB3(155)

Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

BRL 37344 is a selective β₃-adrenoceptor agonist.

BRL 37344 is a selective β₃-adrenoceptor agonist. Studies support the hypothesis that there are peripheral β₃ adrenergic receptors that can reduce food intake and that central β₂ or β₃ adrenergic receptors mediate the peripheral effects of the β₃ agonist.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Hygroscopic; store desiccated.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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A beta-3 adrenergic agonist (BRL-37,344) decreases food intake.

S Tsujii et al.

Physiology & behavior, 63(4), 723-728 (1998-04-02)

This study evaluated the effect of peripheral injections of a beta3 adrenergic agonist, BRL-37,344 on food intake and whether this inhibition could be blocked by a nonspecific beta-adrenergic antagonist, propranolol, given peripherally or into the central nervous system. When BRL-37,344

The selectivity in vitro of the stereoisomers of the beta-3 adrenoceptor agonist BRL 37344.

M A Oriowo et al.

The Journal of pharmacology and experimental therapeutics, 277(1), 22-27 (1996-04-01)

The stimulation by BRL 37344 of lipolysis in rat adipose tissues, and of relaxation of the rat distal colon, is mediated by the beta-3 adrenoceptor. The stereochemical requirements of the beta-3 adrenoceptor are poorly understood. The activities of the four

The protective effects of the β3 adrenergic receptor agonist BRL37344 against liver steatosis and inflammation in a rat model of high-fat diet-induced nonalcoholic fatty liver disease (NAFLD).

Ziwen Wang et al.

Molecular medicine (Cambridge, Mass.), 26(1), 54-54 (2020-06-07)

Our objective was to investigate the efficacy of the beta-3 adrenergic receptor (β3-AR) agonist BRL37344 for the prevention of liver steatosis and inflammation associated with nonalcoholic fatty liver disease (NAFLD). Four groups were established: a control group (given a standard

Beta3-adrenoceptors mediate relaxation of guinea pig taenia caecum by BRL37344A and BRL35135A.

K Koike et al.

European journal of pharmacology, 334(2-3), 217-221 (1997-11-22)

Beta-adrenoceptor-mediated relaxation of guinea pig taenia caecum was investigated by studying the effects of the beta3-adrenoceptor agonists, BRL37344A [(R*,R*)-(+/-)-4-[2'-[2-hydroxy-2-(3-chlorophenyl) ethylamino] propyl] phenoxyacetic acid sodium salt sesquihydrate] and BRL35135A [(R*,R*)-(+/-)-methyl-4-[2-[2-hydroxy-2-(3-chlorophenyl) ethylamine] propyl] phenoxyacetate hydrobromide]. BRL37344A and BRL35135A caused dose-dependent relaxation of

β-Adrenoceptor signaling regulates proliferation and contraction of human bladder smooth muscle cells under pathological hydrostatic pressure.

Junyu Lai et al.

Journal of cellular biochemistry, 120(10), 17872-17886 (2019-06-05)

Partial bladder outlet obstruction (PBOO) promotes bladder detrusor hyperplasia, increases bladder pressure, and decreases bladder compliance. To extensively explore its underlying mechanism, our study aimed to investigate the effect of pathological hydrostatic pressure on human bladder smooth muscle cell (hBSMC)

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Global Trade Item Number

SKU	GTIN
B169-5MG	04061832088815
B169-25MG	04061833426326

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