Key Documents

View All Documentation

C1240

Chlormethiazole hydrochloride

Name: Chlormethiazole hydrochloride
Brand: SIGMA

≥98% (HPLC), GABAA agonist, powder

Synonym(s):

4-methyl-5-(β-chloroethyl)thiazole hydrochloride, 5-(2-Chloroethyl)-4-methylthiazole hydrochloride, Clomethiazole hydrochloride, Somnevrin hydrochloride

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₆H₈ClNS · HCl

CAS Number:

6001-74-7

Molecular Weight:

198.11

UNSPSC Code:

12352200

PubChem Substance ID:

329774745

NACRES:

NA.77

MDL number:

MFCD00673948

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Product Name

Chlormethiazole hydrochloride, ≥98% (HPLC), powder

description

Store desiccated

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

H₂O: soluble >10 mg/mL

originator

AstraZeneca

SMILES string

Cl.Cc1ncsc1CCCl

InChI

1S/C6H8ClNS.ClH/c1-5-6(2-3-7)9-4-8-5;/h4H,2-3H2,1H3;1H

InChI key

OFXYKSLKNMTBHK-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Agonists

Bioactive Small Molecules

Biochem/physiol Actions

Chlormethiazole serves as an anticonvulsant. It is useful in treating alcohol addiction and eclampsia. Chlormethiazole is also useful in treating convulsive status epilepticus. Long term administration of chlormethiazole leads to addiction to the drug.

GABA_A agonist; glycine receptor modulator.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS05,GHS07

signalword

Danger

hcodes

H302,H317,H318

pcodes

P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Chlormethiazole: effectiveness against toxic effects of cocaine in mice.

M Gasior et al.

The Journal of pharmacology and experimental therapeutics, 295(1), 153-161 (2000-09-19)

Chlormethiazole positively modulates the gamma-aminobutyric acid (GABA)(A) receptor complex and is primarily used to treat certain life-threatening neurological events (e.g., refractory seizures and ethanol withdrawal syndrome). On account of several experimental and clinical studies reporting effectiveness against the toxic effects

Pediatric Critical Care Medicine: Basic Science And Clinical Evidence, 985-985 (2007)

Interaction of oxidative stress and neurotrauma in ALDH2-/- mice causes significant and persistent behavioral and pro-inflammatory effects in a tractable model of mild traumatic brain injury.

Rachel C Knopp et al.

Redox biology, 32, 101486-101486 (2020-03-11)

Oxidative stress induced by lipid peroxidation products (LPP) accompanies aging and has been hypothesized to exacerbate the secondary cascade in traumatic brain injury (TBI). Increased oxidative stress is a contributor to loss of neural reserve that defines the ability to

Electrophysiological actions of gamma-aminobutyric acid and clomethiazole on recombinant GABA(A) receptors.

Rachael M Nelson et al.

European journal of pharmacology, 452(3), 255-262 (2002-10-03)

Clomethiazole is a gamma-aminobutyric acid (GABA)-mimetic agent with anticonvulsant, sedative and neuroprotective properties. The pharmacological actions of clomethiazole that underlie its functional profile have not been fully explored, but are known to result from an interaction with the GABA(A) receptor.

A Nurse's Survival Guide to Acute Medical Emergencies (2011)

View All Related Papers

Articles

DISCOVER Bioactive Small Molecules for Neuroscience

Discover Bioactive Small Molecules for ADME/Tox

Global Trade Item Number

SKU	GTIN
C1240-50MG	04061832089584
C1240-10MG	04061832089577

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service