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C4740

Cisapride monohydrate

Name: Cisapride monohydrate
Brand: SIGMA

≥98% (HPLC), 5-HT4 serotonin receptor agonist., solid

Synonym(s):

cis-4-Amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenxamide monohydrate, Acenalin, Cipril

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₉N₃O₄ClF · H₂O

CAS Number:

260779-88-2

Molecular Weight:

483.96

NACRES:

NA.77

PubChem Substance ID:

329775068

UNSPSC Code:

12352200

EC Number:

279-689-7

MDL number:

MFCD03305346

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Product Name

Cisapride monohydrate, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: ~30 mg/mL

originator

Johnson & Johnson

SMILES string

O.CO[C@@H]1CN(CCCOc2ccc(F)cc2)CC[C@@H]1NC(=O)c3cc(Cl)c(N)cc3OC

InChI

1S/C23H29ClFN3O4.H2O/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16;/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29);1H2/t20-,22+;/m0./s1

InChI key

QBYYXIDJOFZORM-IKGOIYPNSA-N

Related Categories

Bioactive Small Molecules

Bioactive Small Molecule Agonists

Biochem/physiol Actions

5-HT₄ serotonin receptor agonist.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

pictograms

GHS05

signalword

Danger

hcodes

H318

pcodes

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000455984

0000440380

0000198214

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Effects of mosapride citrate, a 5-HT4 receptor agonist, on colonic motility in conscious guinea pigs.

Atsuko Inui et al.

Japanese journal of pharmacology, 90(4), 313-320 (2002-12-26)

It is known that 5-HT(4) receptors in the colon of guinea pigs show a distribution similar to that in humans. Thus, we examined the effects of mosapride citrate (mosapride) and cisapride, two 5-HT(4)-receptor agonists, on colonic motility in conscious guinea

Cholinergic neurotransmission participates in increased food intake induced by NMDA receptor blockade.

Mihai Covasa et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 285(3), R641-R648 (2003-05-31)

MK-801, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, enhances gastric emptying while increasing food intake. Although our previously reported results implicate the vagus in MK-801's effect on feeding, it is not clear whether vagal motor fibers participate in the feeding response.

Cisapride and structural analogs selectively enhance 5-hydroxytryptamine (5-HT)-induced purinergic neurotransmission in the guinea pig proximal colon.

M R Briejer et al.

The Journal of pharmacology and experimental therapeutics, 274(2), 641-648 (1995-08-01)

In the guinea pig proximal colon, 5-hydroxytryptamine (5-HT) stimulates neuronal 5-HT1-like receptors to induce relaxations that are mediated by nitric oxide and ATP. In the current study, the effects of cisapride and structural analogs on these 5-HT-induced relaxations were investigated.

Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach.

Henry C Liu et al.

The Journal of pharmacology and experimental therapeutics, 359(1), 215-229 (2016-08-05)

Statistical analysis was performed on physicochemical descriptors of ∼250 drugs known to interact with one or more SLC22 "drug" transporters (i.e., SLC22A6 or OAT1, SLC22A8 or OAT3, SLC22A1 or OCT1, and SLC22A2 or OCT2), followed by application of machine-learning methods

Quantitative Prediction of Human Hepatic Clearance for P450 and Non-P450 Substrates from In Vivo Monkey Pharmacokinetics Study and In Vitro Metabolic Stability Tests Using Hepatocytes.

Haruka Nishimuta et al.

The AAPS journal, 21(2), 20-20 (2019-01-24)

Accurate prediction of human pharmacokinetics for drugs remains challenging, especially for non-cytochrome P450 (P450) substrates. Hepatocytes might be suitable for predicting hepatic intrinsic clearance (CLint) of new chemical entities, because they can be applied to various compounds regardless of the

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Global Trade Item Number

SKU	GTIN
C4740-50MG	04061832089850
C4740-10MG	04061833492697

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