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C5865

CD437

Name: CD437
Brand: SIGMA

≥98% (HPLC), retinoic acid receptor (RAR)γ-selective agonist, solid

Synonym(s):

6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid, AHPN

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About This Item

Empirical Formula (Hill Notation):

C₂₇H₂₆O₃

CAS Number:

125316-60-1

Molecular Weight:

398.49

UNSPSC Code:

12352200

PubChem Substance ID:

24724445

NACRES:

NA.77

MDL number:

MFCD03106506

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Product Name

CD437, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

impurities

~0.5 mol/mol water

color

yellow

mp

271.6-276 °C

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

−20°C

SMILES string

OC(=O)c1ccc2cc(ccc2c1)-c3ccc(O)c(c3)C45CC6CC(CC(C6)C4)C5

InChI

1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)

InChI key

LDGIHZJOIQSHPB-UHFFFAOYSA-N

Gene Information

human ... RARA(5914), RARB(5915), RARG(5916)

Related Categories

Bioactive Small Molecule Agonists

Bioactive Small Molecules

Biochem/physiol Actions

CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000382584

0000181995

0000139873

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Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalis.

Fang Tan et al.

Frontiers in microbiology, 10, 2301-2301 (2019-10-28)

Enterococcus faecalis (E. faecalis), a biofilm-forming pathogen, causes nosocomial infections. In recent years, drug resistance by enterococci has become increasingly severe due to widespread antibiotic abuse. Therefore, novel antibacterial agents are urgently needed. In this study, the synthetic retinoid compound

Takaharu Asano et al.

Frontiers in cardiovascular medicine, 9, 842641-842641 (2022-04-12)

Conventional drug screening methods search for a limited number of small molecules that directly interact with the target protein. This process can be slow, cumbersome and has driven the need for developing new drug screening approaches to counter rapidly emerging

DNA polymerase α-primase facilitates PARP inhibitor-induced fork acceleration and protects BRCA1-deficient cells against ssDNA gaps.

Zuzana Machacova et al.

Nature communications, 15(1), 7375-7375 (2024-08-28)

PARP inhibitors (PARPi), known for their ability to induce replication gaps and accelerate replication forks, have become potent agents in anticancer therapy. However, the molecular mechanism underlying PARPi-induced fork acceleration has remained elusive. Here, we show that the first PARPi-induced

The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progression.

Mark D Long et al.

Oncogene, 38(3), 421-444 (2018-08-19)

Expression levels of retinoic acid receptor gamma (NR1B3/RARG, encodes RARγ) are commonly reduced in prostate cancer (PCa). Therefore, we sought to establish the cellular and gene regulatory consequences of reduced RARγ expression, and determine RARγ regulatory mechanisms. RARG shRNA approaches

Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis.

Almudena Bosch et al.

Breast cancer research : BCR, 14(4), R121-R121 (2012-08-28)

Retinoic acid signaling plays key roles in embryonic development and in maintaining the differentiated status of adult tissues. Recently, the nuclear retinoic acid receptor (RAR) isotypes α, β and γ were found to play specific functions in the expansion and

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Global Trade Item Number

SKU	GTIN
C5865-25MG	04061832954189
C5865-5MG	04061832954196

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