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C5929

Sigma-Aldrich

Calcium carbonate

BioReagent, suitable for insect cell culture, ≥99.0%

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Synonym(s):
Limestone, calcite, calofort u, chalk, marble
Linear Formula:
CaCO3
CAS Number:
471-34-1
Molecular Weight:
100.09
Beilstein:
8008338
EC Number:
207-439-9
MDL number:
MFCD00010906
PubChem Substance ID:
24892821
NACRES:
NA.71

product line

BioReagent

Quality Level

200

Assay

≥99.0%

form

powder

technique(s)

cell culture | insect: suitable

solubility

H2O: soluble (10 g + 20 mL of HCl, dilute to 150 mL with H2O)

density

2.93 g/mL at 25 °C (lit.)

SMILES string

[Ca++].[O-]C([O-])=O

InChI

1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2

InChI key

VTYYLEPIZMXCLO-UHFFFAOYSA-L

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General description

Calcium carbonate (CaCO3) is a ternary ionic compound formed by carbon, oxygen, and calcium. It is one of the most common minerals found in rocks worldwide. It aids in studying the process of biomineralization, where it participates in the formation of various mineral structures including marine sediments, shells of marine organisms, snails, coal balls, pearls, and eggshells. CaCO3 exists in different mineral forms such as calcite, aragonite, and vaterite.

Application

Calcium carbonate buffer has been used as a component of alginate solution for tissue culture, and for preparing conductive alginate-coated electrodes. It has also been used in the preparation of alginate hydrogel for drug delivery.

Biochem/physiol Actions

Calcium carbonate aids in bone formation and mineralization. It is often used as an antacid due to its potent alkalizing properties. Calcium carbonate has good biocompatibility, porous structure, large surface area, and high loading capacity. These properties of calcium carbonate make it favorable to use as a drug delivery system. In addition, the lower solubility of calcium carbonate (CaCO3) makes it effective in reducing the gelation rate and prolonging the working time for alginate gels. Therefore, it is widely used in the preparation of alginate solution.

Features and Benefits

  • BioReagent grade.
  • High level of assay ( ≥99.0%), indicating its purity.
  • Designed for insect cell culture applications.

Storage Class Code

13 - Non Combustible Solids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Calcium carbonate features
Durand N, et al.
Journal of Separation Science (2018)
An in vitro investigation to assess procedure parameters for injecting therapeutic hydrogels into the myocardium
Clive J C, et al.
Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 105(8) (2017)
The 100 most important chemical compounds: a reference guide
Myers R L, et al.
Journal of Separation Science (2007)
The potential of biomimesis in bone tissue engineering: lessons from the design and synthesis of invertebrate skeletons
Green D, et al.
Bone, 30(6) , 810-815 (2002)
Calcium carbonate
Omari MMH, et al.
Analytical profiles of drug substances and excipients, 41 (2016)
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