C8417
N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride
≥98% (TLC), solid, adrenergic neurotoxin
Synonym(s):
DSP-4, N-Ethyl-N-(2-chloroethyl)-2-bromobenzylamine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C11H15BrClN · HCl
CAS Number:
Molecular Weight:
313.06
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
MDL number:
Beilstein/REAXYS Number:
4020910
Product Name
N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride, ≥98%, solid
Quality Level
assay
≥98%
form
solid
color
white
solubility
H2O: 48 mg/mL, 0.1 M NaOH: 7 mg/mL, ethanol: soluble
SMILES string
Cl[H].CCN(CCCl)Cc1ccccc1Br
InChI
1S/C11H15BrClN.ClH/c1-2-14(8-7-13)9-10-5-3-4-6-11(10)12;/h3-6H,2,7-9H2,1H3;1H
InChI key
NDDRNRRNYOULND-UHFFFAOYSA-N
Biochem/physiol Actions
Adrenergic neurotoxin that induces acute and relatively selective degeneration of both central and peripheral noradrenergic nerve terminals.
Preparation Note
Solutions in ethanol, water or 0.1 N NaOH should be freshly prepared.
Disclaimer
Hygroscopic.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Yun-Fei Lü et al.
Frontiers in neural circuits, 11, 66-66 (2017-10-06)
Empathy for pain (vicariously felt pain), an ability to feel, recognize, understand and share the painful emotions of others, has been gradually accepted to be a common identity in both humans and rodents, however, the underlying neural and molecular mechanisms
T Skrebuhhova et al.
Methods and findings in experimental and clinical pharmacology, 21(7), 483-490 (1999-11-02)
[3H]-Ketanserin binding in rat neocortex (frontal and cerebral cortex) after 3-week treatment with desipramine (10 mg/kg) and citalopram (5 mg/kg) in vehicle-, DSP-4- (50 mg/kg) and p-CPA- (350 mg/kg before the beginning of experiments and once per week on the
Delphine Guérin et al.
Behavioral neuroscience, 122(4), 816-826 (2008-08-30)
Noradrenergic projections from the locus coeruleus (LC) project to the olfactory bulb (OB), a cortical structure implicated in odor learning and perceptual differentiation among similar odorants. The authors tested the role of OB noradrenaline (NA) in short-term olfactory memory using
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C8417-100MG | 04061833522295 |
| C8417-250MG | 04061832090009 |