HEL92.1.7

Erythroid cell differentiation studies, induced globin synthesis

Derived from 30 year old male Caucasian. Expresses β-2 microglobulin and Ia antigen. Used in the study of erythroid cell differentiation and globin gene expression. Analogous to Friend cell leukaemia in mice. K-562 has similar characteristics.

Human Caucasian erythroleukaemia

STR-PCR Data: Amelogenin: X,Y
CSF1PO: 10
D13S317: 9,11
D16S539: 11
D5S818: 11
D7S820: 7
THO1: 7
TPOX: 11
vWA: 14,17

Maintain cultures between 3-9x100,000 cells/ml; 5% CO₂; 37°C. Cell growth can be very slow on resuscitation. Stand the culture flask up overnight using 20% FBS.

RPMI 1640 + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).

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This cell line is part of the European Collection of Authenticated Cell Cultures (ECACC), an international repository managed by the United Kingdom Health Security Agency (UKHSA). No licensing agreement is required when either this cell line or the DNA extracted from it are used for internal research purposes only. Any other use of these products is prohibited without the express written permission of UKHSA. Inquiries regarding authorized use of this cell line or its genomic DNA may be directed to culturecollections@ukhsa.gov.uk.