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D0676

Dobutamine hydrochloride

Name: Dobutamine hydrochloride
Brand: SIGMA

≥98% (TLC), powder, α1, β1 and β2-adrenoceptor agonist

Synonym(s):

(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₃NO₃ · HCl

CAS Number:

49745-95-1

Molecular Weight:

337.84

NACRES:

NA.77

PubChem Substance ID:

24277772

UNSPSC Code:

12352116

EC Number:

256-464-1

MDL number:

MFCD00153795

Assay:

≥98%

Form:

powder

Quality level:

200

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Product Name

Dobutamine hydrochloride, ≥98%

Quality Level

200

assay

≥98%

form

powder

originator

Eli Lilly

storage temp.

2-8°C

SMILES string

Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2

InChI

1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H

InChI key

BQKADKWNRWCIJL-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154)

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Bioactive Small Molecule Agonists

Bioactive Small Molecules

Application

Dobutamine hydrochloride has been used:

to treat mouse embryonic fibroblasts for cell death analysis
to inhibit TAZ (transcriptional coactivator with PDZ-binding motif)/YAP (Yes-associated protein) of Hippo pathway and study its effect on tumor cell proliferation
as β1-AR partial agonist to determine its effects on budding of endophilin-mRFP-positive structures by live-cell imaging

Biochem/physiol Actions

Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302 + H312 + H332,H361fd

pcodes

P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Workbook in Practical Neonatology, 239-239 (2014)

Role of p53 in cAMP/PKA pathway mediated apoptosis

Rahimi A, et al.

Apoptosis, 18(12), 1492-1499 (2013)

Programming of Schwann cells by Lats1/2-TAZ/YAP signaling drives malignant peripheral nerve sheath tumorigenesis

Wu LMN, et al.

Cancer Cell, 33(2), 292-308 (2018)

Dobutamine (2018)

Dynamic release and clearance of circulating microparticles during cardiac stress.

Daniel Augustine et al.

Circulation research, 114(1), 109-113 (2013-10-22)

Microparticles are cell-derived membrane vesicles, relevant to a range of biological responses and known to be elevated in cardiovascular disease. To investigate microparticle release during cardiac stress and how this response differs in those with vascular disease. We measured a

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Global Trade Item Number

SKU	GTIN
D0676-50MG	04061833557983
D0676-10MG	04061833557976

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