D1068
DCB
≥98% (HPLC), solid
Synonym(s):
3,3′-Dichlorobenzaldazine, NSC 67224
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About This Item
Empirical Formula (Hill Notation):
C14H10Cl2N2
CAS Number:
Molecular Weight:
277.15
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
solid
storage condition
desiccated
under inert gas
color
yellow
solubility
DMSO: ~6.8 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
Clc1cccc(\C=N\N=C\c2cccc(Cl)c2)c1
InChI
1S/C14H10Cl2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+
InChI key
XMOVWXSCYLINBJ-BEQMOXJMSA-N
Related Categories
Biochem/physiol Actions
3,3′-dichlorobenzaldazine (DCB) serves as an allosteric ligand with neutral cooperativity. It helps to block the positive allosteric regulation of mGluRs (metabotropic glutamate receptor subtype 5 (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) and the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB).
Neutral allosteric modulator of the metabotropic glutamate receptor mGluR5.
Features and Benefits
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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